Sökning: "histone deacetylase inhibitor"

Visar resultat 11 - 15 av 24 avhandlingar innehållade orden histone deacetylase inhibitor.

1. 11. Experimental combination therapy of brain cancer cell models

   Författare :Ana-Maria Marino; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and adults, respectively. We have been investigating if combination therapy using histone deacetylase inhibitors (HDACi) and receptor tyrosine kinase inhibitors (RTKi) will enhance glioblastoma and medulloblastoma cell killing. LÄS MER

3. 12. Notch Signaling in Neuroblastoma and Renal Cell Carcinoma

   Författare :Jonas Sjölund; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; differentiation; clear cell renal cell carcinoma; neuroblastoma; TGF-beta; migration; γ-secretase; valproic acid; cancer; Notch; ERK; von Hippel-Lindau; hypoxia;

   Sammanfattning : The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. LÄS MER

4. 13. HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?

   Författare :Atosa Estekizadeh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented in several cancer types. LÄS MER

5. 14. From Single Gene to Whole Genome Studies of Human Transcription Regulation

   Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
   Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

   Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER

7. 15. Epigenetic mechanisms and regulatory aspects of human cancer and neural progenitor cells : implications for diagnosis and therapy

   Författare :Monira Akhtar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Epigenetic is defined as heritable modification or properties of the functional genome that are not directly embedded in the DNA sequence. Epigenetic changes include DNA methylation, histone modifications and RNA-mediated gene silencing. LÄS MER