Sökning: "higher-order drug combination analysis"

Hittade 2 avhandlingar innehållade orden higher-order drug combination analysis.

  1. 1. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

    Författare :Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

    Sammanfattning : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. LÄS MER

  3. 2. Sex, drugs and intersecting risks : HIV among people who belong to more than one key population in the United States

    Författare :Lina Nerlander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The HIV epidemic in the United States (US) is mainly concentrated in so-called ‘key populations’ including men who have sex with men (MSM) and people who inject drugs (PWID). In addition, other groups such as people of low socioeconomic status and people belonging to some ethnic minorities have a higher prevalence of HIV. LÄS MER