Sökning: "high-throughput screening"

Visar resultat 11 - 15 av 167 avhandlingar innehållade orden high-throughput screening.

  1. 11. Introducing weak affinity chromatography to drug discovery with focus on fragment screening

    Författare :Minh-Dao Duong-Thi; Sten Ohlson; Brian Dymock; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity LC-MS; fragment-based drug discovery; fragment screening; high throughput; mass spectrometry; stereoisomer; enantiomer; thrombin; weak affinity chromatography; WAC; WAC-MS.; Biomedical Sciences; Biomedicinsk vetenskap; Biokemi; Biochemistry;

    Sammanfattning : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. LÄS MER

  3. 12. Improved Techniques for High-Throughput Molecular Diagnostics

    Författare :Mario Curcio; KTH; []
    Nyckelord :DNA; Molecular Diagnostics;

    Sammanfattning : The amount of information derived from sequencing the humangenome is leading to an exponential increase in the rate atwhich genes and genetic disorders are mapped and characterized.As a consequence, the demand for genetic testing is alsodramatically increasing. LÄS MER

  4. 13. Molecular Screening for Target Discovery in Cancer

    Författare :Mårten Fryknäs; Anders Isaksson; Ulf Pettersson; Hugh Salter; Uppsala universitet; []
    Nyckelord :Genetics; Cancer; Drug resistance; Microarray; High-throughput screening; Genetik;

    Sammanfattning : Cancer is one of the major causes of death in the western world. Resistance to anti-cancer drugs and diagnostic difficulties are major obstacles to successful treatment. LÄS MER

  5. 14. Genetic Screening in Patients Suspected of Inherited Bleeding Disorders

    Författare :Marcus Fager Ferrari; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bleeding; Inherited Bleeding Disorders; Platelet Dysfunction; Thrombocytopenia; Genetic Screening; High-Throughput Sequencing; STX11; STXBP2; UNC13D; FGB; COL1A1; COL3A1; COL5A1; COL5A2; GNE; Sialic Acid; Oseltamivir;

    Sammanfattning : Inherited bleeding disorders constitute a heterogeneous group of genetic diseases, affecting virtually all major components of the hemostatic system. The diagnostics are potentially complex, and a high proportion of patients remain without a conclusive diagnosis following work-up. LÄS MER

  7. 15. High-throughput screening of solid-phase extraction materials using mass spectrometry

    Författare :Kishore Jagadeesan; Avdelningen för Biomedicinsk teknik; []
    Nyckelord :mass spectromery; protein separation; sample preparation; Molecularly imprinted polymer; Data analysis; Data visualization; Miniaturisation; Proteomics;

    Sammanfattning : In biomarker analysis, sample preparation plays a crucial step in order to extract, isolate and concentrate the analytes of interest. Among the various sample preparation techniques, solid phase extraction (SPE) is one of the most common and popular, due to the high enrichment factor, good recovery, low consumption of organic solvents and the possibility to automate (off- or on-line) the whole process. LÄS MER