Sökning: "high-throughput screen"

Visar resultat 6 - 10 av 60 avhandlingar innehållade orden high-throughput screen.

  1. 6. Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum

    Författare :Kimi Drobin; Jochen M. Schwenk; Peter Nilsson; Ulrika Qundos; Angela Silveira; Maria Pernemalm; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; plasma; serum; biomarker discovery; osteoporosis; inflammatory bowel disease; Crohn s disease; ulcerative colitis; Medical Technology; Medicinsk teknologi;

    Sammanfattning : Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. LÄS MER

  3. 7. Droplet microfluidics for directed evolution of biocatalysts

    Författare :Staffan Sjöström; Helene Andersson Svahn; Florian Hollfelder; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Droplet microfluidics; Enzymes; directed evolution; high throughput screening; Bioteknologi; Biotechnology;

    Sammanfattning : Biocatalysts, biologically derived catalysts, are of great importance for a wide range of industrial applications. They are used in the production of for example foods, pharmaceuticals and biofuels. Improving biocatalysts commonly relies on directed evolution, i.e. LÄS MER

  4. 8. Identification of novel modulators of protein synthesis and nucleolar biology using high throughput phenotypic screens

    Författare :Alba Corman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein synthesis and ribosome biogenesis are fundamental steps in gene expression and constitute the most energy demanding processes in living cells. Dysregulation of these processes is associated to a variety of human disorders including cancer, metabolic diseases, immunodeficiency, neurological and developmental disorders, and physiological aging. LÄS MER

  5. 9. Experimental and computational exploration of enzyme sequence space

    Författare :Elzbieta Rembeza; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; high-throughput-screening; protein annotation; enzyme discovery; enzyme sequence space; oxidases;

    Sammanfattning : Millions of enzymes with desirable features or new exciting activities can be found in organisms occupying diverse niches all around the earth. However, enzyme studies tend to be biased towards characterisation of representatives from eukaryotes, model organisms, or disease-causing bacteria. LÄS MER

  7. 10. Rift Valley fever : consequences of virus-host interactions

    Författare :Maria Baudin; Magnus Evander; Clas Ahlm; Göran Bucht; Tomas Bergström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rift Valley fever; Rift Valley fever virus; viral haemorrhagic fever; miscarriage; entry; charge; carbohydrates; high-throughput screening; antiviral; cell-based assay; medicinsk virologi; Medical Virology;

    Sammanfattning : Rift Valley fever virus (RVFV) is a mosquito-borne virus which has the ability to infect a large variety of animals including humans in Africa and Arabian Peninsula. The abortion rate among these animals are close to 100%, and young animals develop severe disease which often are lethal. LÄS MER