Sökning: "high-throughput screen"

Visar resultat 11 - 15 av 60 avhandlingar innehållade orden high-throughput screen.

1. 11. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

   Författare :Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

   Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER

3. 12. Ion channels in drug discovery : focus on biological assays

   Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

   Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER

4. 13. The ADAR editing enzymes as therapeutic targets

   Författare :Kajsa Fritzell; Marie Öhman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Editing by deamination of adenosine to inosine (A-to-I) in double-stranded RNA is a common event in the human transcriptome. Altered levels of the essential ADAR1 activity are associated with disease. Children with mutations in the ADAR1 gene suffer from fatal Aicardi-Goutières syndrome (AGS) characterized by aberrant interferon expression. LÄS MER

5. 14. Bioinformatics tools for discovery and evaluation of biomarkers : Applications in clinical assessment of cancer

   Författare :Benjamin Ulfenborg; Björn Olsson; Karin Klinga-Levan; Erik Larsson Lekholm; Högskolan i Skövde; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Algorithms; biomarkers; machine learning; classification; cancer; microRNA database; microRNA discovery; partial least squares; Medical sciences; Medicin; Bioinformatik; Bioinformatics; Biomedicin;

   Sammanfattning : Cancer is a disease characterized by abnormal proliferation of cells in the body and ranks as the second leading cause of death worldwide. In order to improve cancer patient care, a major focus of cancer research is to discover biomarkers. LÄS MER

7. 15. Preclinical investigation of novel therapies against neuroblastoma

   Författare :Karin Hansson; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

   Sammanfattning : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. LÄS MER