Sökning: "high-resolution mass spectrometry"

Visar resultat 1 - 5 av 85 avhandlingar innehållade orden high-resolution mass spectrometry.

  1. 1. Characterisation of natural dissolved organic matter with liquid chromatography and high resolution mass spectrometry

    Författare :Claudia Patriarca; Jonas Bergquist; Lars Tranvik; Per J.R. Sjöberg; Jeffrey A. Hawkes; Norbert Hertkorn; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquatic carbon cycle; dissolved organic matter; DOM; high resolution mass spectrometry; online liquid chromatography; organic matter characterization; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Dissolved organic matter (DOM) is one of the most heterogeneous and complex mixture on Earth. DOM plays a crucial role in biogeochemical processes on the global scale and it is essential to sustain and regulate the biological processes in aquatic ecosystems. LÄS MER

  3. 2. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

    Författare :Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. LÄS MER

  4. 3. Analytical developments and applications of ambient mass spectrometry imaging : Visualizing challenging analytes and understanding chemical mechanisms of ischemic stroke

    Författare :Leonidas Mavroudakis; Ingela Lanekoff; Daniel Globisch; Malcolm Clench; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry imaging; ischemic stroke; mass spectrometry; isomers; spatial metabolomics; host-guest; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Bioanalytical methods that provide spatial information on molecular distributions are important for deep understanding of chemical mechanisms in health and disease. For instance, the localized action of drugs and metabolites can provide valuable information on metabolism in specific cellular regions, which would not be possible with bulk analysis. LÄS MER

  5. 4. New Materials and Improved Ambient Techniques in Mass Spectrometry

    Författare :Nicolò Riboni; Leopold Ilag; Elisa Robotti; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Solid Phase Microextraction; Ambient Mass Spectrometry; Desorption Electrospray Ionization; Paper Spray Ionization; Cavitands; BTEX; New Psychoactive Substances; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Mass spectrometry (MS) is used in several fields, e.g. biology, environmental monitoring, medicine and forensics due to excellent qualitative and quantitative capabilities. The development of new instrumental setups and ionization sources is crucial to analyze a variety of compounds at trace levels. LÄS MER

  7. 5. Fluorine mass balance in wildlife and consumer products : How much organofluorine are we missing?

    Författare :Lara Schultes; Jonathan P. Benskin; Michael McLachlan; Jörg Feldmann; Elsie M. Sunderland; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PFASs; PFOS; fluorine mass balance; organofluorine; EOF; TF; wildlife; consumer products; combustion ion chromatography; high resolution mass spectrometry; suspect screening; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : Per- and polyfluoroalkyl substances (PFASs) are a class of anthropogenic pollutants. Many PFASs are highly persistent and have been linked to adverse effects in humans. According to latest estimates, there are more than 4700 PFASs in global commerce, which poses immense challenges for environmental monitoring. LÄS MER