Sökning: "high-penetrance alleles"

Hittade 3 avhandlingar innehållade orden high-penetrance alleles.

1. 1. Molecular genetic studies of colorectal cancer

   Författare :Xiaolei Zhou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Colorectal cancer CRC ; high-penetrance alleles; low-penetrance alleles; autism spectrum disorder ASD ; MSI; microarray; metastasis; hMLH3; APC; MYH; TJP3.;

   Sammanfattning : Colorectal cancer (CRC) is one of the leading causes of morbidity and mortality due to cancer in the Western countries. Epidemiological studies have shown that at least 20-30% of CRCs have a potentially identifiable genetic cause. LÄS MER

3. 2. Genetic studies of colorectal cancer

   Författare :Johanna Skoglund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :colorectal cancer; linkage analysis; TGFBR1; case-control study; meta-analysis;

   Sammanfattning : Colorectal cancer is the third most commonly diagnosed cancer worldwide with an incidence rate of over 1 million cases per year. A genetic contribution has been suggested to be involved in around 35% of all colorectal cancer cases. LÄS MER

4. 3. Search for susceptibility loci and candidate genes for breast cancer

   Författare :Qianren Jin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Breast cancer is the most frequent cancer among women in the western world. Family history is a wellestablished and important risk factor for breast cancer. Both a population-based twin study and a study based on a large family cancer database have suggested that hereditary factors account for about a quarter of breast cancers. LÄS MER