Sökning: "high-dose therapy"

Visar resultat 6 - 10 av 58 avhandlingar innehållade orden high-dose therapy.

  1. 6. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

    Författare :Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

    Sammanfattning : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. LÄS MER

  3. 7. High-Dose Radioimmunotherapy and Extracorporeal Depletion in A Syngeneic Rat Tumor Model

    Författare :Linda Mårtensson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : ABSTRACT Radioimmunotherapy (RIT) consists of using monoclonal antibodies (mAbs) recognizing tumor-selective antigens, as carriers of cytotoxic radionuclides to tumor tissue. RIT has been effective in lymphoma but less successful in solid tumors. LÄS MER

  4. 8. High dose rate brachytherapy boost for localized prostate cancer : clinical and patient-reported outcomes

    Författare :Thomas Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Localized prostate cancer; radiotherapy; HDR brachytherapy; health related quality of life; questionnaires; side effects;

    Sammanfattning : Curative treatment of prostate cancer is controversial. The therapeutic effects of surgery and radiotherapy (RT) have hitherto proved to be similar, why other endpoints such as health related quality of life (HRQoL) stay important in decision-making. LÄS MER

  5. 9. Absorbed dose and biological effect in light ion therapy

    Författare :Malin Hollmark; Irena Gudowska; Oliver Jäkel; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Light ion therapy; absorbed dose calculation; analytical pencil beam model; Monte Carlo; radiobiological modeling; Radiological physics; Radiofysik; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : Radiation therapy with light ions improves treatment outcome for a number of tumor types. The advantageous dose distributions of light ion beams en-able exceptional target conformity, which assures high dose delivery to the tumor while minimizing the dose to surrounding normal tissues. LÄS MER

  7. 10. Modeling of dose and sensitivity heterogeneities in radiation therapy

    Författare :Kristin Wiklund; Bengt K. Lind; Iuliana Toma-Dasu; Marco Zaider; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Monte Carlo simulations; Tumor control probability; Modeling; Beam characterization; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : The increased interest in the use of light ion therapy is due to the high dose conformity to the target and the dense energy deposition along the tracks resulting in increased relative biological effectiveness compared to conventional radiation therapy. In spite of the good clinical experience, fundamental research on the characteristics of the ion beams is still needed in order to be able to fully explore their use. LÄS MER