Sökning: "high-dose therapy"

Visar resultat 21 - 25 av 58 avhandlingar innehållade orden high-dose therapy.

  1. 21. lmprovement of 177Lu-octreotate treatment of small-intestine neuroendocrine tumors by hyperfractionation

    Författare :Mikael Elvborn; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide receptor radionuclide therapy; PRRT; somatostatin receptor; SSTR; apoptosis; gene expression; epigenetic effects;

    Sammanfattning : Neuroendocrine tumor incidence is steadily rising, and the late diagnosis often results in metastatic disease and current treatments mostly prolong life and in-crease quality of life without increasing cure rate. 177Lu-octreotate was recently approved for treatment of neuroendocrine tumors, but the dosage scheme should be optimized. LÄS MER

  3. 22. On Quality in Radiotherapy Treatment Plan Optimisation

    Författare :Hunor Benedek; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pareto optimisation; Pareto fronts; Dose prediction; Machine learning; Deliverable treatment plans; Volumetric modulated arc therapy; IMRT; patient-specific plan quality; plan quality; Multi Criteria Optimisation; Automated Treatment Planning;

    Sammanfattning : Radiotherapy is one of the essential treatments used in the fight against cancer. The goal of radiotherapy is to deliver a high dose of ionising radiation to the tumour volume and at the same time minimise the effect on healthy tissue by reducing the radiation to critical organs. LÄS MER

  4. 23. Stem cell transplantation in multiple myeloma : clinical aspects and experimental gene transfer studies

    Författare :Bo Björkstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :multiple myeloma; bone marrow transplantation; allogeneic; autologous; prognostic factors; hemato-poietic stem eells; gene therapy; gene transfer; retrovirus; basic fibroblast growth factor;

    Sammanfattning : Multiple myeloma (MM) is a hematological malignant disease considered essentially incurable despite its sensitivity to cytotoxic chemotherapeutic drugs and radiation. High-dose chemo/radiotherapy with allogeneic- or autologous hematopoietic stem cell transplantation (tx) can induce a disease-free state and may prolong survival and offer an improved quality of life to MM patients. LÄS MER

  5. 24. Glucocorticoid-induced adrenal insufficiency

    Författare :Margret Einarsdottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid; adrenal insufficiency; mortality;

    Sammanfattning : Background: Glucocorticoids (GCs) are effective in treating many diseases and are widely used. However, glucocorticoid treatment can down-regulate the hypothalamic-pituitary-adrenal axis and lead to glucocorticoid-induced adrenal insufficiency. LÄS MER

  7. 25. Medication-related osteonecrosis of the jaw : occurence, risk factors, pathogenesis & treatment

    Författare :Fredrik Hallmer; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The antiresorptive drugs bisphosphonates and denosumab arewidely used to preserve bone strength by inhibiting osteoclast mediatedbone resorption. High dose intravenous bisphosphonatesand high dose denosumab are mainly used to treat skeletal relatedevents in patients with metastatic bone disease such as metastaticbreast cancer and metastatic prostate cancer or in patients withmultiple myeloma. LÄS MER