Sökning: "high-dose therapy"

Visar resultat 1 - 5 av 52 avhandlingar innehållade orden high-dose therapy.

  1. 1. Dose Escalation with High Dose Rate Brachytherapy or Protons in Curative Radiotherapy of Prostate Cancer

    Författare :Lennart Åström; Lars Holmberg; Gunilla Enblad; Henrik Grönberg; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; radiotherapy; brachytherapy; high dose rate; protons; PSA bounce;

    Sammanfattning : The aim of the thesis was to study the outcome and side effects after dose-escalated radiotherapy with high dose rate brachytherapy (HDR-BT) or proton beam therapy (PBT) boost in prostate cancer.The first cohorts of men in Sweden treated with either HDR-BT or PBT in combination with conventional photon beam therapy (2 Gray (Gy) fractions to 50 Gy) were analysed. LÄS MER

  2. 2. Modelling late toxicity in hypofractionated radiation therapy

    Författare :Niclas Pettersson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Hypofractionation; normal tissue complication probability; modelling; linear-quadratic model; fractionation sensitivity; late toxicity; radiation-induced rib fracture; genitourinary toxicity; stereotactic body radiation therapy; high-dose-rate brachytherapy; multimodality radiation therapy; patient-reported outcomes; prostate cancer; nsclc;

    Sammanfattning : In hypofractionated radiation therapy (RT), the treatment is delivered by few fractions with high doses per fraction. This is in contrast to conventionally fractionated RT where the total dose is delivered in many fractions with low doses per fraction. LÄS MER

  3. 3. Mathematical Modelling of Dose Planning in High Dose-Rate Brachytherapy

    Författare :Björn Morén; Torbjörn Larsson; Åsa Carlsson Tedgren; Sebastiaan Breedveld; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer is a widespread type of diseases that each year affects millions of people. It is mainly treated by chemotherapy, surgery or radiation therapy, or a combination of them. One modality of radiation therapy is high dose-rate brachytherapy, used in treatment of for example prostate cancer and gynecologic cancer. LÄS MER

  4. 4. Treatment Planning of High Dose-Rate Brachytherapy - Mathematical Modelling and Optimization

    Författare :Björn Morén; Torbjörn Larsson; Åsa Carlsson Tedgren; Bram Gorissen; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Cancer is a widespread class of diseases that each year affects millions of people. It is mostly treated with chemotherapy, surgery, radiation therapy, or combinations thereof. High doserate (HDR) brachytherapy (BT) is one modality of radiation therapy, which is used to treat for example prostate cancer and gynecologic cancer. In BT, catheters (i. LÄS MER

  5. 5. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

    Författare :Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

    Sammanfattning : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. LÄS MER