Sökning: "high-cholesterol diet"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden high-cholesterol diet.

  1. 1. Studies on apolipoprotein E and high cholesterol diet as risk factors for neurodegeneration

    Författare :S M Atiqur Rahman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Elevated level of plasma cholesterol is a well-established risk factor for cardiovascular disease, and emerging evidence suggest that it plays a role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). The relations between dietary habits and neurodegeneration are complex, as the brain is selectively separated from peripheral circulation by the blood brain barrier (BBB). LÄS MER

  3. 2. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

    Författare :Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER

  4. 3. From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease

    Författare :Susanne Akterin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epidemiological studies have provided evidence that high cholesterol levels in midlife and lack of antioxidants could render people more susceptible to develop AD. The aim of this thesis project was to get a more profound view of how cholesterol and oxidative stress could modify the development of Alzheimer s disease (AD) on the molecular level, by studying mechanisms of signal transduction. LÄS MER

  5. 4. Effects of growth hormone on cardiovascular risk factors and atherosclerosis

    Författare :Maria Leonsson Zachrisson; Göteborgs universitet; []
    Nyckelord :growth hormone; pituitary deficiency; dietary fat; cholesterol; low density; lipoprotein; intima-media thickness; IL-6; CRP; TNF-á;

    Sammanfattning : Hypopituitary patients with growth hormone (GH) deficiency (GHD) have increasedmorbidity and mortality from cardiovascular disease (CVD). GH treatment has both beneficialand potentially negative cardiovascular effects. LÄS MER

  7. 5. Role of platelet-derived growth factor B in cholesterol and glucose metabolism

    Författare :Tian Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe hemorrhage and edema. LÄS MER