Sökning: "high resolution mass spectrometry"

Visar resultat 16 - 20 av 130 avhandlingar innehållade orden high resolution mass spectrometry.

  1. 16. Development and Application of Software Tools for Mass Spectrometry Imaging

    Författare :Patrik Källback; Per E. Andrén; Per Svenningsson; Anna Nilsson; Benjamin Bowen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; DESI; msIQuant; quantitation; neurotransmitters; drugs; derivatization; brain; compression; data entropy reduction;

    Sammanfattning : Mass spectrometry imaging (MSI) has been extensively used to produce qualitative maps of distributions of proteins, peptides, lipids, neurotransmitters, small molecule pharmaceuticals and their metabolites directly in biological tissue sections. Moreover, during the last 10 years, there has been growing demand to quantify target compounds in tissue sections of various organs. LÄS MER

  3. 17. Amino acids with relevance to health, climate and the environment : Development of mass spectrometric methods

    Författare :Javier Zurita; Leopold Ilag; Ulrika Nilsson; Margareta Törnqvist; Natalia Tretyakova; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amino acids; LC MS; fixed-charge derivatization; BMAA; chiral separation; pheromones; arctic aerosols; serum albumin adducts; benzo[a]pyrene diol epoxides; high-resolution MS; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Amino acids play vital roles in health, either in their native form or chemically modified. Some studies have linked certain non-proteinogenic amino acids to neurodegenerative diseases, such as in the case of β-methylaminoalanine (BMAA). LÄS MER

  4. 18. Label free analysis and spatial distribution of molecular lipids in brain tissue and cells using mass spectrometry imaging

    Författare :Amir Saeid Mohammadi; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry Imaging; Secondary Ion Mass Spectrometry Imaging; Matrix Assisted Laser desorption Ionization; Lipids; Brain tissue;

    Sammanfattning : Lipids are important inherent components in brain and cell membranes, which play significant biological roles in cell function. Identification and localization of specific biomolecules such as peptides and lipids within cellular membranes is currently a major challenge in metabolomics and biological studies. LÄS MER

  5. 19. Analysis of drugs and proteins in biological matrices, using different types of sample preparations and mass spectrometry

    Författare :Aljona Saleh; Ingrid Granelli; Jonas Bergquist; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioanalysis; drugs; proteins; liquid chromatography; two-dimensional liquid chromatography; mass spectrometry; Analytical Chemistry; analytisk kemi;

    Sammanfattning : This thesis describes bioanalysis of small and large molecules in biological matrices and includes screening of illegal drugs in urine with high resolution mass spectrometer, bioanalysis of MTH1 inhibitors in mice plasma and quantification of proteins in plasma and cell lysates.Screening of illegal drugs was based on high resolving power mass spectrometer (QTOF) and the results were compared to immunoassays. LÄS MER

  7. 20. Spatial analysis of lipids in tissue samples applying mass spectrometry imaging

    Författare :Masoumeh Dowlatshahi Pour; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SIMS; MALDI; Mass spectrometry imaging; Lipid; ME-SIMS; Sample preparation;

    Sammanfattning : Lipids are important naturally occurring components in all living cellular organisms. They serve as the main building blocks of cellular membranes, participate in many signaling pathways and are also stored as an energy source. LÄS MER