Sökning: "high resolution mass spectrometry"
Visar resultat 11 - 15 av 129 avhandlingar innehållade orden high resolution mass spectrometry.
11. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization
Sammanfattning : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. LÄS MER
12. Managing and Exploring Large Data Sets Generated by Liquid Separation - Mass Spectrometry
Sammanfattning : A trend in natural science and especially in analytical chemistry is the increasing need for analysis of a large number of complex samples with low analyte concentrations. Biological samples (urine, blood, plasma, cerebral spinal fluid, tissue etc. LÄS MER
13. Efficient algorithms for highly automated evaluation of liquid chromatography - mass spectrometry data
Sammanfattning : Liquid chromatography coupled to mass spectrometry (LC‐MS) has due to its superiorresolving capabilities become one of the most common analytical instruments fordetermining the constituents in an unknown sample. Each type of sample requires a specificset‐up of the instrument parameters, a procedure referred to as method development. LÄS MER
14. Structural Determination of Drug Metabolites from Doping Classed Compounds Using Mass Spectrometry
Sammanfattning : Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged. LÄS MER
15. Analysis of noncovalent and covalent protein-ligand complexes by electrospray ionisation mass spectrometry
Sammanfattning : In this thesis, the application of electrospray ionisation mass spectrometry (ESI-MS) to the analysis of intact proteins is demonstrated. In papers I and II, the use of ESI-MS for the analysis of noncovalent protein-ligand complexes were discussed. LÄS MER