Sökning: "high definition mass spectrometry"

Hittade 5 avhandlingar innehållade orden high definition mass spectrometry.

  1. 1. Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment

    Författare :Daniel Ansari; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; artificial neural networks; apicidin; centralization; early detection; epigenetics; high definition mass spectrometry; MUC4; pancreatic cancer; pancreaticoduodenectomy; prognostic factors; xenograft model; treatment;

    Sammanfattning : Background: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. LÄS MER

  3. 2. Process Analytical Tools for the Monitoring and Characterization of Bacterial Toxins

    Författare :Martin Hedström; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioteknik; Biotechnology; protein degradation; mass spectrometry; Bacterial toxins; Biosensor;

    Sammanfattning : In the era of proteomics, glycomics and ultimately metabolomics, with constantly increasing knowledge regarding the human biosystem, the number of specialized therapeutic agents which will be developed against different diseases is predicted to be on the upswing. An increasing portion of these new drugs will, according to recent predictions (Labrou, 2003), be of proteinaceous origin produced according to biotechnological standards. LÄS MER

  4. 3. Statistical Feature Selection : With Applications in Life Science

    Författare :Roland Nilsson; Jesper Tegnér; Johan Björkegren; Sepp Hochreiter; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Machine learning; supervised learning; classification; dimemsionality reduction; multiple testing; gene expression; microarray; cancer; Bioinformatics; Bioinformatik;

    Sammanfattning : The sequencing of the human genome has changed life science research in many ways. Novel measurement technologies such as microarray expression analysis, genome-wide SNP typing and mass spectrometry are now producing experimental data of extremely high dimensions. LÄS MER

  5. 4. Cancer Evolution under Chemotherapy Treatment

    Författare :Kaname Uno; Cancercellers evolution; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; Wilms tumor; chemotherapy resistance; ascites; spheroids; diffuse anaplasia;

    Sammanfattning : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). LÄS MER

  7. 5. Sialic acid-dependent binding specificities of Helicobacter pylori and influenza virus. Importance of different parts of the binding sequences

    Författare :Petra Johansson; Göteborgs universitet; []
    Nyckelord :sialic acid; carbohydrates; Helicobacter pylori; influenza virus; binding specificities; glycosphingolipids;

    Sammanfattning : Many viruses and bacteria adhere to host cell glycoconjugates in a specific manner, utilizing selected carbohydrate sequences. The aim of this work was to investigate at a molecular level the interactions of two important human pathogens, influenza virus and Helicobacter pylori, with sialylated carbohydrate structures. LÄS MER