Sökning: "heterozygosity"

Visar resultat 1 - 5 av 93 avhandlingar innehållade ordet heterozygosity.

  1. 1. Dispersal, inbreeding and fitness in natural populations

    Författare :Bengt Hansson; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immigration; inbreeding; inbreeding depression; heterozygosity; microsatellite; great reed warbler; bird; Djurekologi; Animal ecology; philopatry; heritability; founder event; dispersal; bottleneck;

    Sammanfattning : To evaluate how inbreeding affects the viability of small populations, it is crucial to determine what constitutes a population (i.e., the number of breeders in local patches and the degree of dispersal), and also to estimate the reproductive consequences of philopatry and emigration. LÄS MER

  3. 2. Infidelity in Birds – Causes and Consequences of Extra-pair Paternity

    Författare :Jakob Augustin; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; extra-pair paternity; genetic benefits; heterozygosity; sex ratio; Riparia riparia; Tringa totanus; Vanellus vanellus; Charadrius alexandrinus;

    Sammanfattning : Forty years ago, more than 90% of bird species were classified as monogamous and not very exciting systems for studies of e.g. sexual selection. LÄS MER

  4. 3. Molecular Pathogenesis of Cervical Carcinoma : Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

    Författare :Xinrong Hu; Björn Hagmar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. LÄS MER

  5. 4. Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancers

    Författare :Nasir K. Kamat; Ulf Rannug; Giovanni Corso; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; Genetic instability; Microsatellites instability; Loss of heterozygosity; Mismatch repair; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. LÄS MER

  7. 5. Targeting allelic loss in colorectal cancer

    Författare :Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

    Sammanfattning : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. LÄS MER