Sökning: "heteroaromatic"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet heteroaromatic.

  1. 1. New methods for the synthesis of N-heteroaromatics and imines

    Författare :Kenji Kopf; Belén Martín Matute; Joseph P. A. Harrity; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; heterocyclic; heteroaromatic; atropisomer; pyridine; pyrimidine; MOF; amine coupling; catalysis; benzannulation; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis is divided in four chapters, containing the work realised in two universities and has as the aim the synthesis of nitrogen-containing compounds. The first chapter describes the project realised at The University of Sheffield. LÄS MER

  2. 2. Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions

    Författare :Alexander Dahlqvist; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitor; Heterocycles; C-glycoside; Medicinal chemistry; Organic chemistry; Hydroboration; Diastereoselective; Galactose;

    Sammanfattning : Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. LÄS MER

  3. 3. Transition metal-catalyzed reduction of carbonyl compounds : Fe, Ru and Rh complexes as powerful hydride mediators

    Författare :Elina Buitrago; Hans Adolfsson; Robert Morris; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; amino acid; N-heterocyclic carbene; iron; ruthenium; rhodium; mechanistic investigation; kinetic study; asymmetric transfer hydrogenation; hydrosilylation; Organic Chemistry; organisk kemi;

    Sammanfattning : A detailed mechanistic investigation of the previously reported ruthenium pseudo-dipeptide-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones was performed. It was found that the addition of alkali metals has a large influence on both the reaction rate and the selectivity, and that the rate of the reaction was substantially increased when THF was used as a co-solvent. LÄS MER

  4. 4. Detection of Biomolecules: Syntheses and Studies of Minor Groove Binding Unsymmetrical Cyanine Dyes and Chromogenic Enzyme Substrates

    Författare :Jonas Karlsson; Chalmers University of Technology; []
    Nyckelord :palladium-catalysed cross-couplings; optical spectroscopy; minor groove binding; DNA; cyanine dye; enzyme; intercalation; fluorescence; chromogenic;

    Sammanfattning : Visualisation or detection of biomolecules is usually achieved by the use of fluorescent or highly coloured chromophores. The work presented in this thesis deals with the development of new chromogenic substrates for the detection of enzyme activity, and new DNA-binding fluorescent dyes for staining of DNA. LÄS MER

  5. 5. Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates

    Författare :Marcin Bielawski; Berit Olofsson; Antonio Togni; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Hypervalent Iodine Compounds; One-Pot Synthesis; Regiospecific Synthesis; Aromatic Substitution; Aryl Iodides; Arenes; Boronic Acids; Heteroaromatics; Arylations; Reaction Mechanisms; Density Functional Calculations; Large Scale Synthesis; Organic synthesis; Organisk syntes; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts.  The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. LÄS MER