Sökning: "hereditary breast and ovarian cancer"

Visar resultat 16 - 20 av 23 avhandlingar innehållade orden hereditary breast and ovarian cancer.

  1. 16. Precision medicine of ovarian cancer for adults and children : molecular, hereditary and clinical aspects

    Författare :Sandra Wessman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ovarian cancer was 2018 ranked as the eighth most common cancer diagnosis and cause of death in women. Of these, the most common histological type is high-grade serous carcinoma. LÄS MER

  3. 17. Genetic studies in familial breast cancer

    Författare :Moraima Zelada Hedman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This study focuses on familial breast cancer, where some alteration is supposed to be inherited and predispose the individuals to breast cancer. Even when the majority of breast cancer cases are sporadic, a familial breast cancer study might light on over certain genes involved in the etiology of the disease. LÄS MER

  4. 18. Epidemiological studies on breast cancer risk factors and screening

    Författare :Xinhe Mao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors of women and cancer risk among their relatives. Specifically, four studies were conducted using data from Swedish national registers, the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) cohort, and the Linné-Bröst1 (Libro-1) cohort. LÄS MER

  5. 19. Evaluation of genetic cancer predisposition and potential cancer genes

    Författare :Yaxuan Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer (hTP53rc) syndrome. LFS is a rare inherited cancer syndrome characterized by premenopausal breast cancer, soft tissue sarcoma, brain tumor, osteosarcoma, and adrenocortical carcinoma. LÄS MER

  7. 20. Molecular genetic analysis of human breast cancer

    Författare :Catherine M Phelan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cancer being implicated in 5-10% of these cases. Two highly penetrant hereditary breast cancer genes are known; BRCA1 (17q) and BRCA2 (13q), which also confer an increased risk of cancer at other sites. LÄS MER