Sökning: "hepatobiliary system"

Hittade 5 avhandlingar innehållade orden hepatobiliary system.

  1. 1. The Hepatobiliary Transport of Rosuvastatin In Vivo

    Författare :Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Sammanfattning : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. LÄS MER

  2. 2. Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI

    Författare :Nils Dahlström; Örjan Smedby; Torkel Brismar; Anders Ynnerman; Carsten Thomsen; Linköpings universitet; []
    Nyckelord :Liver; spleen; hepatobiliary system; liver function; MRI; DCE-MRI; Gd-EOBDTPA; Gd-BOPTA; pharmacokinetic; hepatocyte; relaxivity.; MEDICINE; MEDICIN;

    Sammanfattning : The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients.Ten healthy volunteers were examined with both contrast agents in a 1. LÄS MER

  3. 3. Magnetic Resonance Imaging of the Hepatobiliary System Using Hepatocyte-Specific Contrast Media

    Författare :Nils Dahlström; Örjan Smedby; Torkel Brismar; Anders Ynnerman; Lennart Blomqvist; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diagnostic radiology; Diagnostisk radiologi;

    Sammanfattning : There are two Gadolinium-based liver-specific contrast media for Magnetic Resonance Imaging on the market, Gd-BOPTA (MultiHance®, Bracco Imaging, Milan, Italy) and Gd-EOB-DTPA (Primovist®, Bayer Schering Pharma, Berlin, Germany). The aim of this study in two parts was to evaluate the dynamics of biliary, parenchymal and vascular enhancement using these contrast media in healthy subjects. LÄS MER

  4. 4. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

    Författare :Ilse R Dubbelboer; Hans Lennernäs; Erik Sjögren; Hartmut Derendorf; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery system; in vivo release; PBPK modelling; hepatocellular carcinoma; doxorubicin; transarterial chemoembolization; drug disposition; Biofarmaci; Biopharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). LÄS MER

  5. 5. Autoimmune hepatitis : life, death and in-between

    Författare :Åsa Danielsson Borssén; Mårten Werner; Soo Aleman; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; autoimmune hepatitis; autoimmune liver disease; hepatocellular carcinoma; surveillance; pregnancy; pregnancy outcome; cirrhosis; fibrosis; epidemiology; cause of death; medicin; Medicine;

    Sammanfattning : Background Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that is overrepresented in women (75% of cases). Studies have described a 10-year survival after diagnosis near to that of the general population, but less is known about the long-term survival. LÄS MER