Sökning: "hepatitis B virus"

Visar resultat 1 - 5 av 63 avhandlingar innehållade orden hepatitis B virus.

  1. 1. Hepatitis B virus replication and integration

    Författare :Simon B. Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; replication; integration; HBV DNA; HBsAg;

    Sammanfattning : Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no liver disease and express the e antigen (HBeAg). LÄS MER

  3. 2. Genomic and transcriptomic profiles in chronic hepatitis B infection

    Författare :Johan Ringlander; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; hepatitis delta virus; integration; deep sequencing; cirrhosis; HCC;

    Sammanfattning : Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are attributed to HBV infection. The virus is adapted to the human host and has developed mechanisms to evade immunity. LÄS MER

  4. 3. Genetic variability of hepatitis B virus in chronic infection

    Författare :Charles Hannoun; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; mutation; genotype; phylogeny; ; Recombination; coinfection; interferon; response;

    Sammanfattning : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. LÄS MER

  5. 4. The hepatitis B virus – Insights into genetic variability, evolution and Bayesian phylogeographic inference

    Författare :Mikael Ingman; Malmö Klinisk virologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatit B; evolutionsbiologi; fylogeni; Hepatitis B; evolutionary dynamics; Phylogeography;

    Sammanfattning : In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. LÄS MER

  7. 5. Geographic and genetic diversity of hepatitis B

    Författare :Erik Alestig; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; genotype; phylogeny; molecular epidemiology; sequence analysis; mutation;

    Sammanfattning : Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead to the evolution of 8 established (A-H) and 2 putative genotypes (I-J), each corresponding to a rather well-defined geographical distribution. LÄS MER