Sökning: "heparan sulfate"

Visar resultat 6 - 10 av 98 avhandlingar innehållade orden heparan sulfate.

  1. 6. Heparan Sulfate Dependent Mechanisms of Amyloidosis

    Författare :Fredrik Noborn; Jin-ping Li; Ulf Lindahl; Giampaolo Merlini; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amyloidosis; Heparan sulfate; Transthyretin; Serum amyloid A; Amyloid-beta; lipoproteins; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : A common theme in amyloid disorders is the deposition of disease-specific protein aggregates in tissues. Amyloid proteins bind to heparan sulfate (HS), a sulfated glycosaminoglycan, and HS has been found to promote the aggregation process. LÄS MER

  3. 7. Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

    Författare :Paul O'Callaghan; Xiao Zhang; Lars Lannfelt; Jeremy Turnbull; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloidosis; amyloid-β; apolipoprotein E; astrocytes; glia; heparanase; heparan sulfate; heparan sulfate proteoglycans; microglia; neuroinflammation; Geriatrics; Geriatrik; Cellforskning; Cell Research; Neuroscience; Neurovetenskap; Pathology; Patologi;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder, with extensive evidence implicating the misfolding, aggregation and deposition of the amyloid-β (Aβ) peptide as central to the pathogenesis. Heparan sulfate (HS) is an interactive glycosaminoglycan, attached to core proteins as HS proteoglycans (HSPGs). LÄS MER

  4. 8. Heparan Sulfate Biosynthesis – Clues from Knockout Mice

    Författare :Johan Ledin; Lena Kjellén; John Gallagher; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; heparan sulfate; biosynthesis; gene targeting; embryonic development; proteoglycans; NDST; N-deacetylase N-sulfotransferase; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : In the extracellular space, many specialized proteins are located to support cells and to mediate cell-cell signalling. One class of such molecules is heparan sulfate (HS) proteoglycans, which are proteins with different properties and locations but all of them decorated with long unbranched HS polysaccharide chains. LÄS MER

  5. 9. Enzymes involved in heparan sulfate chain elongation : Function of a novel family of tumor suppressors?

    Författare :Thomas Lind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; biosynthesis; glycosyltransferase; EXT1; EXT2; UDP-glucosedehydrogenase; KfiC; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan associated with many physiological functions such as regulation of growth factor action and cell adhesion. The HS polysaccharide is synthesized by alternating addition of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (GlcNAc) units from the corresponding UDP-sugar precursors. LÄS MER

  7. 10. Cellular regulation of heparan sulfate structure and function

    Författare :Fariba Safaiyan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Heparan sulfate; structure; biosynthesis; sulfation; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Heparan sulfate (HS) is a sulfated glycosaminoglycan found on cell surfaces and in the extracellular matrix as HS proteoglycans. HS is synthesized as a polymer of alternating glucuronic acid and N-acetylglucosamine units. LÄS MER