Sökning: "henrik lindman"

Hittade 4 avhandlingar innehållade orden henrik lindman.

  1. 1. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

    Författare :Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

    Sammanfattning : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. LÄS MER

  3. 2. HER2-receptor quantification in breast cancer patients by imaging with ABY-025 Affibody and PET

    Författare :Ali Alhuseinalkhudhur; Henrik Lindman; Jens Sörensen; Mark Lubberink; Irina Velikyan; Rimma Axelsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; Breast cancer; HER2; Affibody; ABY-025; Molecular imaging; Kinetic modelling; Brain metastasis;

    Sammanfattning : Breast cancer is the most common malignancy in women worldwide. Human epidermal growth factor receptor type 2 (HER2) is overexpressed in up to 20% of breast cancer cases and is considered an important prognostic factor and a therapeutic target. LÄS MER

  4. 3. Epidermal Melanocyte Response to Radiotherapy

    Författare :Per Fessé; Henrik Lindman; Ingela Turesson; Johan Ahlgren; Jan Nyman; Catharine West; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanocytes; fractionated radiotherapy; ΔNp63; MITF; PAX3; SOX10; p53; p21; BMI1; pRb; CXCR2; DNA-DSB; 53BP1; CXCR2;

    Sammanfattning : Cutaneous interfollicular melanocytes protect the skin from UV-radiation (UVR), and their response to UVR is well established. To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy (RT) has not been explored. LÄS MER

  5. 4. Pharmacometric Evaluation of Biomarkers to Improve Treatment in Oncology

    Författare :Ida Netterberg; Lena Friberg; Mats Karlsson; Elisabet I. Nielsen; Henrik Lindman; Amit Roy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Biomarkers; Oncology; Population PKPD Modeling; NONMEM; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Cancer is a family of many different diseases with substantial heterogeneity also within the same cancer type. In the era of personalized medicine, it is desirable to identify an early response to treatment (i.e., a biomarker) that can predict the long-term outcome with respect to both safety and efficacy. LÄS MER