Sökning: "hemophilia A"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden hemophilia A.

1. 1. Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A

   Författare :João A. Abrantes; Mats Karlsson; Elisabet I. Nielsen; Siv Jönsson; Ron Mathôt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bayesian forecasting; coagulation factor VIII; dose adaptation; hemophilia haemophilia A; inter-occasion variability; NONMEM; pharmacodynamics; pharmacokinetics; pharmacometrics; therapeutic drug monitoring; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches. LÄS MER

3. 2. Pharmacometric models to inform dose selection and study design : Applied in hemophilia and tuberculosis

   Författare :Alan Faraj; Ulrika S. H. Simonsson; Joakim Nyberg; Ron Mathot; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug development; pharmacometrics; pharmacokinetics; pharmacodynamics; non-linear mixed effect models; hemophilia; tuberculosis; dose selection; study design; pediatric extrapolation;

   Sammanfattning : While tuberculosis is a global pandemic, hemophilia is a rare disease which many have not heard of. Due to tuberculosis mainly being a problem in developing countries and hemophilia being a rare disease, they are not as heard of as other diseases such as cancer or metabolic diseases which are on the rise in Western societies. LÄS MER

4. 3. Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease

   Författare :Jenny Klintman; Malmö Klinisk koagulationsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hemophilia A; inhibitors; non-neutralizing anti-FVIII antibodies; thrombin generation assay; ELISA;

   Sammanfattning : Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life have increased. LÄS MER

5. 4. HEMOPHILIA A AND B WITH SPECIAL REFERENCE TO INHIBITOR DEVELOPMENT AND EXPERIMENTAL STUDIES OF FACTORS VIII AND IX

   Författare :Karin Knobe; Enheten för pediatrisk hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; inhibitors; mutations; Factor IX; Factor VIII; coagulation; hemophilia A and B; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : The general objective of the research underlying this dissertation was to conduct clinical and basic scientific studies to further elucidate the hemophilia and the coagulation process, with the goal of improving the care of families with these disorders. More specific aims were to evaluate epidemiological, genetic, clinical, and biochemical aspects of the development of inhibitors (antibodies) against FVIII and FIX in Swedish patients with hemophilia A and B (papers I, II, and III). LÄS MER

7. 5. The affects towards and perceptions of the self and significant others in hemophiliacs and diabetics

   Författare :Claudia Lament; Institutionen för psykologi; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychology; Psychoanalysis; Self Perception; Hemophilia; Diabetics; Psykologi;

   Sammanfattning : The Affects Towards And Perceptions Of The Self And Significant Others in Hemophiliacs and Diabetics The studies in this dissertation investigated the feelings towards and ways of perceiving the self and significant others in twenty-seven patients with hemophilia between the ages of 16-39 to discern how their perceptual-affect states are organized. Secondly, the relationship between bleeds and affect states was also examined. LÄS MER