Sökning: "hematopoietic stem cell mice"
Visar resultat 1 - 5 av 80 avhandlingar innehållade orden hematopoietic stem cell mice.
1. Identification of Unique Hematopoietic Stem Cell Properties
Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER
2. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development
Sammanfattning : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. LÄS MER
3. Consequences of Shb Deficiency on Hematopoietic Cell Function
Sammanfattning : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. LÄS MER
4. Molecular regulation of hematopoietic stem cells
Sammanfattning : Hematopoietic stem cells (HSCs) are ultimately responsible for the all mature blood cell production. They can primarily be found in the bone marrow (BM) at a low frequency (~0.02%). LÄS MER
5. Molecular Mechanisms in Hematopoietic Stem Cell Aging
Sammanfattning : The blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. LÄS MER