Sökning: "hematopoiesis"
Visar resultat 11 - 15 av 137 avhandlingar innehållade ordet hematopoiesis.
11. Functional studies of Wilms’ tumor gene 1 (WT1) in hematopoiesis and leukemia
Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. LÄS MER
12. Expression and role of the cytokine tyrosine kinase receptor flt3 in early hematopoiesis
Sammanfattning : Mature blood cells are crucial for life, but they have a short lifetime and thus have to be replaced. These mature blood cells are produced by lineage restricted progenitors, which themselves are generated by rare multipotent hematopoietic stem cells (HSCs) in a highly dynamic process called hematopoiesis. LÄS MER
13. Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem Cells
Sammanfattning : The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. LÄS MER
14. Hox transcription factors in hematopoiesis
Sammanfattning : Hematopoiesis is a lifelong, dynamic process in which a small number of pluripotent hematopoietic stem cells (HSC) residing in the bone marrow (BM) give rise to billions of mature blood cells of both myeloid and lymphoid origin each day. This enormous capacity of HSC has been utilized in BM transplantations for 4 decades and is also very important for future gene therapy. LÄS MER
15. Genetic modeling of the Hippo pathway in hematopoietic stem cells
Sammanfattning : Hematopoiesis is the process of blood formation from a limited pool of hematopoietic stem cells (HSCs). These rare stem cells can both self-renew to maintain the HSC pool, and differentiate to continuously replenish lost blood cells. The mechanisms of HSC regulation are not fully known. LÄS MER