Sökning: "hematologic malignancies"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden hematologic malignancies.
1. Trisomies in Hematologic Malignancies
Sammanfattning : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. LÄS MER
2. Clinical - cytogenetic correlations in malignant hematologic disorders
Sammanfattning : In the present thesis, clinicogenetic correlations are investigated in a large population-based series of acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), acute lymphoblastic leukemia, and chronic myeloid leukemia, for which the karyotypes were analyzed at the same center. The karyotypic pattern, i.e. LÄS MER
3. Sexuality in patients treated for hematologic malignancies - Problems and need for support from patients’ and nurses’ perspectives
Sammanfattning : Aim: The overall aim of this thesis was to describe and explore how sexuality, body image and HRQoL were affected in patients treated for hematologic malignancies, and their need for support. A further aim was to describe nurses’ conceptions of dialogues about sexuality. LÄS MER
4. Computational biology of blood disorders: Patterns and algorithms
Sammanfattning : The morphological and molecular characterization and of malignant blood disorders is pivotal to ensure a correct diagnosis, guide therapy, and, in the longer term, to identify their molecular causes. Over the past several years, new technology has increased our abilities to describe, typecast, and understand hematologic malignancies beyond what was previously possible. LÄS MER
5. Gene Expression Studies of Hematologic Malignacies
Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER