Sökning: "helices"

Visar resultat 1 - 5 av 101 avhandlingar innehållade ordet helices.

  1. 1. Transmembrane helices : tails, turns and snorkels

    Författare :Magnus Monné; Donald Engelman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : The assembly and structure of membrane proteins are intimately related. Targeting and insertion of membrane proteins into the endoplasmatic reticulum (ER) membrane involve many components that facilitate the folding of the native structure. LÄS MER

  3. 2. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding

    Författare :Tuuli Minttu Virkki de Marothy; Arne Elofsson; William Dowhan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein folding; hydrophobicity; translocon; transmembrane helix; marginally hydrophobic transmembrane helices; orientational preference; positive inside rule; aquaporin 1; Biochemistry; biokemi;

    Sammanfattning : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. LÄS MER

  4. 3. Versatile Association Behavior in Mixtures of Oppositely Charged Amphiphiles : From DNA-Like Assembly of Supramolecular Helices to Coacervation in Chiral Surfactant Systems

    Författare :Guanqun Du; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bile salts; Block copolymers; Oppositely charged polymer-surfactant systems; Co-assembly; BS sequestrants; Gemini surfactants; Supramolecular helices; Hexagonal packing; Chirality; Thermoresponsive behavior; Scattering; Tomography; Calorimetry;

    Sammanfattning : As biological surfactants, bile salts (BSs), play important roles in biological processes, i.e., food digestion, but also in BS-related diseases, as well as in applications. LÄS MER

  5. 4. Integration of Transmembrane Helices into the Endoplasmic Reticulum

    Författare :Tara Hessa; Gunnar von Heijne; James Bowie; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : Membrane proteins reside in cell and organelle membranes. They play significant roles in many processes vital to living cells. Receptors and ion channels are examples of membrane proteins that regulate the physiological state of the cell and are attractive targets for drug development. LÄS MER

  7. 5. Cotranslational protein biogenesis in Escherichia coli monitored by force profile analysis

    Författare :Felix Nicolaus; Gunnar von Heijne; Ross Dalbey; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; cotranslational protein biogenesis; membrane protein; soluble protein; transmembrane helices; force profile analysis; arrest peptide; biokemi; Biochemistry;

    Sammanfattning : Proteins are a diverse class of biomolecules that carry out many essential functions across all organisms. They can either be found in aqueous compartments or embedded in biological membranes of the cell and are called soluble or membrane proteins, respectively. LÄS MER