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1. 1. Provoked vestibulodynia : studies on pain genetics and pain co-morbidity

   Författare :Ulrika Heddini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :provoked vestibulodynia;

   Sammanfattning : Objective: The purpose of this thesis was to investigate a possible genetic predisposition for developing provoked vestibulodynia (PVD), focusing on previously defined single nucleotide polymorphisms (SNPs) in three genes with a known influence on endogenous pain modulation: GCH1, OPRM1 and 5HT-2A. We also investigated the effects of any potential interactions between these SNPs and the use of hormonal contraceptives, serum levels of β-endorphin and symptoms of anxiety and depression, on the risk of developing PVD and general pain sensitivity. LÄS MER