Sökning: "heck"

Visar resultat 1 - 5 av 52 avhandlingar innehållade ordet heck.

1. 1. Palladium(II)-Catalyzed Heck Reactions : Domino Reactions, Decarboxylations, Mechanistic Studies & Continuous Flow Applications

   Författare :Ashkan Fardost; Mats Larhed; Patrick Guiry; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium II ; dft; reaction mechanisms; esi-ms; heck; decarboxylation; microwave; continuous flow;

   Sammanfattning : This thesis describes research efforts dedicated to the development of palladium(II)-catalyzed oxidative Heck and Heck/Suzuki domino reactions, and the applications of a new microwave heating technology, purpose-built for continuous flow in organic synthesis.Paper I describes the development of a ligand-modulated approach for attaching aryl groups to a chelating vinyl ether. LÄS MER

3. 2. Targeted proteomics methods for protein quantification of human cells, tissues and blood

   Författare :Fredrik Edfors; Mathias Uhlén; Albert Heck; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteomics; mass spectrometry; protein quantification; stable isotope standard; parallel reaction monitoring; immuno-enrichment; Bioteknologi; Biotechnology;

   Sammanfattning : The common concept in this thesis was to adapt and develop quantitative mass spectrometric assays focusing on reagents originating from the Human Protein Atlas project to quantify proteins in human cell lines, tissues and blood. The work is based around stable isotope labeled protein fragment standards that each represent a small part of a human protein-coding gene. LÄS MER

4. 3. On the analysis of antibody repertoires

   Författare :August Jernbom Falk; Peter Nilsson; Anna Månberg; Albert J.R. Heck; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody repertoire; autoantibodies; serology; microarray; bead array; affinity proteomics; psychosis; SARS-CoV-2; COVID-19; post-COVID-19 condition; immunoglobulin; IgG; Biotechnology; Bioteknologi;

   Sammanfattning : The antibody repertoire is the ensemble of antibodies found in an individual at a given time. It displays high heterogeneity between individuals while being both largely temporally stable within an individual and rapidly responsive to immunological challenge. LÄS MER

5. 4. Gas-Phase Protein Structure Under the Computational Microscope : Hydration, Titration, and Temperature

   Författare :Erik Marklund; David van der Spoel; Albert Heck; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; gas phase; proteins; micelles; proton transfer; Grothuss mechanism; kinetics; Physics; Fysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

   Sammanfattning : Although the native environment of the vast majority of proteins is a complex aqueous solution, like the interior of a cell, many analysis methods for assessing chemical and physical properties of biomolecules require the sample to be aerosolized; that is, transferred to the gas-phase. An important example is electrospray-ionization mass spectrometry, which can provide a wide range of information about e. LÄS MER

7. 5. The development and use of product platforms in single-family industrialized house building

   Författare :Djordje Popovic; Fredrik Elgh; Tobias Schauerte; Carin Rösiö; Detlef Heck; Jönköping University; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; House-building industry; Modern methods of construction; Production strategy; Platform-based development; Product lifecycle management; PLM; BIM; Engineer-to-order;

   Sammanfattning : Single-family industrialized house building is a trade characterized by a complete predefinition of products with off-the-shelf solutions offered to a market niche. Limited customization is included in the offerings in the form of a modular configuration of predefined components. LÄS MER