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Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

1. 1. A multivariate approach to QSAR

   Författare :Sven Hellberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QSAR; beta-adrenergic agents; haloalkanes; halogenated anesthetics; peptides; fractional factorial design; multivariate data analysis; principal components PC ; partial least squares PLS ;

   Sammanfattning : Quantitative structure-activity relationships (OSAR) constitute empirical analogy models connecting chemical structure and biological activity. The analogy approach to QSAR assume that the factors important in the biological system also are contained in chemical model systems.The development of a QSAR can be divided into subproblems:1. LÄS MER

3. 2. Design of Glutathione Transferase Variants for Novel Activities with Alternative Substrates

   Författare :Abeer Shokeer; Bengt Mannervik; Francoise Raffalli-Mathieu; David Josephy; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Organic chemistry; Organisk kemi; Biokemi; Biochemistry; Organisk kemi; Organic Chemistry;

   Sammanfattning : Glutathione transferases (GSTs) play a pivotal role in cellular defense, since they are main contributors to the inactivation of genotoxic compounds of exogenous and endogenous origins. Directed evolution was used to improve the catalytic activities of Theta class GST T1-1 toward different substrates. LÄS MER