Sökning: "hESC"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet hESC.

  1. 1. Optimisation of human embryonic stem cell derivation and culture : towards clinical quality

    Författare :Susanne Ström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hESC;

    Sammanfattning : For clinical grade human embryonic stem cell (hESC) lines, a robust derivation and culture system without any substances having animal origin would be optimal. The general aims of these studies have been to gradually improve our hESC derivation and cultures. LÄS MER

  3. 2. FGF signaling in specification of hESC-derived definitive endoderm

    Författare :Jacqueline Ameri; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Diabetes affects around 200 million people worldwide. Curing diabetes would require the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. LÄS MER

  4. 3. Free to Conform : A Comparative Study of Philanthropists’ Accountability

    Författare :Noomi Weinryb; Maria Blomgren; Tammar B. Zilber; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; accountability; philanthropists; organization theory; human embryonic stem cell hESC research funding; philanthropy; civil society; nonprofit sector;

    Sammanfattning : Those who are very wealthy may also be extremely free. Independently wealthy philanthropists epitomize this type of freedom. They seem to be able to act in whichever way they please, as long as they respect the limits of the law. Their freedom also implies that they do not experience as much accountability as other funders. LÄS MER

  5. 4. Cell transplantation with human mesenchymal or embryonic stem cells to the heart : experimental, molecular, immunological and echocardiographic studies

    Författare :Karl-Henrik Grinnemo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human mesenchymal stem cells; human embryonic stem cells; human cardiomyocyte; Islet-1; Nkx2.5; stem cell; xenotransplantation; rejection; FoxP3 T-cells; tolerance; CTLA4Ig; anti- CD40L; LFA-1;

    Sammanfattning : Background: Human mesenchymal stem cells (hMSC), human embryonic stem cells (HESC) and human fetal cardiomyocyte progenitor cells (HFCP) all represent possible candidate cells for regeneration of damaged myocardium. Although they represent cell types with many positive attributes, their capacity to engraft, to differentiate into mature cardiomyocytes, to improve myocardial function and their immunological properties are the focus of these studies. LÄS MER

  7. 5. Human Embryonic Stem Cells; A novel model system for early human development

    Författare :Karin Gertow; Lars Ährlund-Richter; Henrik Semb; Karolinska Institute; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; Human embryonic stem cells; model system; differentiation; xeno-grafting; teratoma; development; karyotype; chromosomal integrity; variant.;

    Sammanfattning : Human embryonic stem cells (HESC) have since their first description in 1998 been recognized as a theoretically endless source of cells capable of differentiation into any somatic cell type. Although great attention has been given to their potential use in cell- based therapy, they are equally important as research tools for studies on early human development, both normal and diseased. LÄS MER