Sökning: "gut-brain barrier"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden gut-brain barrier.

1. 1. The gut-brain axis and alcohol-mediated behaviours: the amylin story

   Författare :Aimilia Lydia Kalafateli; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reward; mesolimbic dopamine system; addiction; calcitonin; IAPP;

   Sammanfattning : Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of mortality and morbidity. The currently available pharmacotherapies show varied efficacy, leading to the investigation of new neurochemical targets for alcohol. LÄS MER

3. 2. Gut microbiota to counteract metabolic disorders and neuroinflammation : Impact of dietary factors and their potential to prevent Alzheimer’s disease

   Författare :Nittaya Marungruang; Avdelningen för livsmedel och läkemedel; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; gut microbiota; metabolic disorders; inflammation; neuroinflammation; lingonberries; dietary fibre; gut barrier; blood-brain barrier;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia. Increased accumulations of senile plaques and tangles are the known neuropathological hallmarks of AD. However, the exact triggers for such protein accumulations, leading to cognitive impairment and important morphological alteration in AD, are still elusive. LÄS MER

4. 3. Neuro-immuno-regulation of inflammation in the colonic mucosa : Focus on mast cells and eosinophils in bowel disorders

   Författare :Maria Teresa Casado Bedmar; Åsa Keita; Johan D Söderholm; Marie Carlson; Melanie Gareau; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mast cells; Eosinophils; Vasoactive intestinal polypeptide; Neuro-immune; Intestinal barrier; Irritable bowel syndrome; Inflammatory bowel diseases; Ussing chamber; Advance image analysis;

   Sammanfattning : Intestinal homeostasis is key to control uptake across the mucosa and protect from harmful substances. Disturbances in the bidirectional communication between the gut and the brain are implicated in irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD), being Crohn’s disease (CD) and ulcerative colitis (UC) the two most common IBD subtypes. LÄS MER

5. 4. lntestinal microenvironment, epithelial barrier interactions and human milk oligosaccharide supplementation in irritable bowel syndrome

   Författare :Cristina Iribarren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colonoids; epithelium; gut microbiota-host interaction; human milk oligosaccharides; intestinal milieu; irritable bowel syndrome; metabolites; microbiota; mucosal border;

   Sammanfattning : Alterations of the microbiota-host interactions at the mucosal border may be of importance in symptom generation in irritable bowel syndrome (IBS), a disorder of gut-brain interaction. Hence, microbiota-targeted interventions may benefit some patients by beneficially modulating the intestinal microenvironment. LÄS MER

7. 5. Glycerol esters of butyric and valeric acids counteract diet-related disorders : Prevention of metabolic disturbances induced by high-fat intake

   Författare :Thao Duy Nguyen; Avdelningen för livsmedel och läkemedel; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short-chain fatty acids; lipid metabolism; cholesterol; gut microbiota; high-fat diet; inflammation; succinic acid; intestinal permeability; tight junction proteins; gut-brain barrier; apolipoprotein E; rats;

   Sammanfattning : Short-chain fatty acids (SCFAs), gut metabolites formed from indigestible dietary components by the colonic microbiota, are associated with numerous health effects, and may be responsible for the beneficial effects, at least in part, associated with dietary fibre. High-fat diets are known to cause low-grade inflammation in the body, but SCFAs are suggested to counteract unfavourable effects induced by these types of diets. LÄS MER