Sökning: "group IIA phospholipase A2"

Hittade 4 avhandlingar innehållade orden group IIA phospholipase A2.

  1. 1. Proteoglycans, group IIA phospholipase A2, and lipoproteins.Potential involvement in atherogenesis

    Författare :Peter Sartipy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; group IIA phospholipase A2; proteoglycans; lipoproteins; inflammation;

    Sammanfattning : Atherosclerosis is a multifactorial complex disease characterized by a focal accumulation of ApoB-100 containing lipoproteins, extracellular matrix (ECM), and cells in the arterial intima accompanied by an inflammatory reaction. In vivo and in vitro data supports the hypothesis that sulfated extracellular proteoglycans may be responsible for the selective retention of low density lipoproteins (LDL) in the arterial wall. LÄS MER

  3. 2. Studies on the structure, function and expression of phospholipase A2

    Författare :Pontus Larsson Forsell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Phospholipase A2 (PLA2) enzymes are widely distributed and the enzymes possess different functions such as a role in digestion and inflammation. PLA2 catalyzes the hydrolysis of the sn-2 acylester bond of phospholipids, yielding a free fatty acid and a lysophospholipid. LÄS MER

  4. 3. Mechanisms involved in the regulation of secretory phospholipase A2 Type IIA expression in human arterial smooth muscle cells. Potential role in atherogenesis

    Författare :Helena Peilot; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Experimental and clinical evidence indicates that secretory phospholipase A2 group IIA (sPLA2-IIA) contributes to atherogenesis. Activity of sPLA2-IIA may be pro-atherogenic both in the circulation leading to altered lipoprotein profile and/or locally in the artery wall where it contributes to lipid accumulation both intra and extra cellularly. LÄS MER

  5. 4. Atherogenic lipoproteins and their interaction with proteoglycans

    Författare :Christofer Flood; Göteborgs universitet; []
    Nyckelord :apolipoprotein B; atherosclerosis; LDL; proteoglycan; sPLA2; ; retention;

    Sammanfattning : Atherosclerosis is a multi-factorial disease and its pathogenesis is still unclear. However, accumulating evidence during recent years has led to the concept that subendothelial retention of atherogenic lipoproteins is the initiating event in atherogenesis. LÄS MER