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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. T cell and antibody responses in Plasmodium falciparum malaria and their relation to disease susceptibility

    Författare :Salah Eldin Farouk; Marita Troye-Blomberg; Hannah Akuffo; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P. falciparum; Malaria; Granulysin; Fulani; Schizont; Immunology; Immunologi;

    Sammanfattning : Malaria antigen-induced polarization of T cells into effectors Th1 and/or Th2 cells and their subsequent release of cytokines is known to affect antibody production. This thesis includes studies on early innate responses to the parasite, with a focus on γδT cells, and acquired specific responses in African sympatric ethnic tribes. LÄS MER

  3. 2. Defense-peptides against mycobacteria

    Författare :Charlotte M A Linde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Antimicrobial peptides; NK-lysin; granulysin; PR-39; Mycobacterium;

    Sammanfattning : Several members of the genus Mycobacterium can cause serious infections in both man and animal. One of the world's most serious infectious diseases, tuberculosis, is caused by the pathogen Mycobacterium tuberculosis. Specific defense to tuberculosis/mycobacteriosis is dependent on the individual's ability to mount a proficient immune response. LÄS MER

  4. 3. Local immune responses in tuberculosis : cytolytic effector functions at the site of mycobacterium tuberculosis infection

    Författare :Sayma Rahman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite recent advances in tuberculosis (TB) research, shortage of knowledge still exists that limits the host-pathogen interactions in human TB. Cell-mediated immunity has been shown to confer protection in TB, although the relative importance of cytolytic T cells (CTLs) expressing granule-associated effector molecules perforin and granulysin is debated. LÄS MER

  5. 4. Genetic studies of familial hemophagocytic lymphohistiocytosis

    Författare :Kim Göransdotter Ericson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial hemophagocytic lymphohistiocytosis FHL ; PRF1 gene; MUNC13-4 gene; NK cells; cytotoxic T lymphocytes;

    Sammanfattning : The main contribution from this thesis is a refined knowledge of locus heterogeneity in familial hernophagocytic lympbohistiocytosis (FHL) and a further characterization of corresponding clinical and immunological phenotypes. Familial hemophagocytic lymphohistiocytosis is a fatal autosomal recessive immune deficiency clinically characterized by fever, cytopenia, hepatosplenomegaly, and hemophagocytosis. LÄS MER

  7. 5. T cell mediated immunity in malaria and mycobacterial infection : a protective role for gd+ T cells

    Författare :Shewangizaw Worku; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malaria; Plasmodium falciparum; Plasmodium. vivax; Mycobacteria; Mycobacterium tuberculosis; BCG; T lymphocytes; T cell receptor; [gamma][delta] T cells; [alpha][beta] T cells;

    Sammanfattning : T cell mediated immunity is essential against intracellular infections. Studies of cell mediated immunity are important for the optimal design and development of effective vaccines. Identifying correlates of protective immunity will also enable measurement of vaccine efficiency. LÄS MER