Sökning: "gram negative septic shock"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden gram negative septic shock.

1. 1. Modulating Organ Dysfunction in Experimental Septic Shock : Effects of Aminoglycosides, Antiendotoxin Measures and Endotoxin Tolerance

   Författare :Markus Castegren; Jan Sjölin; Claes Frostell; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipopolysaccharide; animal model; pig; tobramycin; endotoxin elimination; immunoparalysis; secondary sepsis; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : Sepsis is a common diagnose in the intensive care population, burdened with a high mortality. The systemic inflammatory reaction underlying the development of septic organ dysfunction can be modeled using Gram-negative bacterial lipopolysaccharide, endotoxin. LÄS MER

3. 2. Antibiotic-induced Bacterial Toxin Release – Inhibition by Protein Synthesis Inhibitors

   Författare :Gunilla Hjerdt-Goscinski; Jan Sjölin; Monica Lundholm; Inga Odenholt; Ingrid Nilsson-Ehle; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; Endotoxin; LPS; exotoxin; SpeA; penicillin-binding protein; aminoglycosides; clindamycin; β-lactam antibiotics; severe sepsis; septic shock; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

   Sammanfattning : Toxic products, such as endotoxin from the gram-negative and exotoxin from the gram-positive bacteria, are the most important initiators of the inflammatory host response in sepsis. In addition to antibacterial treatment, numerous attempts have been made to interfere with the exaggerated proinflammatory cascade initiated by the toxins. LÄS MER

4. 3. Hemodynamic and cardiometabolic studies in patients with distributive circulatory dysfunctions : with special reference to the effects of the beta-1-adrenoreceptor agonist prenalterol

   Författare :Sebastian Reiz; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aortic aneurysm surgery; gram negative septic shock; hemodynamics; myocardial metabolism; thermodilution; thoracic epidural block; volume loading; prenalterol;

   Sammanfattning : A total of 49 patients were studied, using invasive hemodynamic techniques with systemic arterial, pulmonary artery and right atrial pressure recordings together with thermodilution cardiac output determinations. Sixteen of the patients were also subjected to cardiometabolic studies, using measurement of coronary sinus blood flow by the continuous thermodilution technique and analyses of oxygen content and lactate concentration in the systemic and coronary circulation. LÄS MER

5. 4. On the role of HMGB1 and resistin in severe sepsis and septic shock

   Författare :Jonas Sundén-Cullberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Severe sepsis and septic shock are serious manifestations of infectious diseases. Mortality ranges from over 30 % in severe sepsis up to 60% in septic shock. Early antibiotic treatment and intensive care are mainstays of therapy, but outside of this, new treatments have only marginally improved survival. LÄS MER

7. 5. Experimental septic shock – Effects of endotoxemia with special reference to pathophysiological responses in the pig

   Författare :Ewa Söderberg; Miklós Lipcsey; Mats B Eriksson; Anders Larsson; Jan Sjölin; Sten Lindahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endotoxin; inflammatory response; animal model; timing; steroid treatment; NGAL; Calprotectin; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Sammanfattning : Sepsis and septic shock are conditions, with severe outcome or in many cases death. Sepsis is a systemic inflammatory response trigger by bacteraemia but systemic inflammatory response can also be triggered by major trauma, major surgery, pancreatitis, severe burns etc. LÄS MER