Sökning: "gram negative bacteria"
Visar resultat 21 - 25 av 209 avhandlingar innehållade orden gram negative bacteria.
Sammanfattning : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. LÄS MER
Sammanfattning : The objective of this thesis is to contribute to the understanding of the interactions between metals and microorganisms with respect to * Toxicity of metals (Cd, Cu, Hg, Zn) * Mineralization of metal-organic complexes (citric acid, histidine) * Metal adsorption (Cs, Sr, Eu, Hg, Zn, As) Most of the studies were made on the gram-negative bacterium Klebsiella oxytoca, but the work also involved a Serratia as as well as mixed cultures of microorganisms from soil systems. Most previous studies, reported in the literature, on the toxic effects of metals on microorganisms have been performed at high nutrient levels, despite the fact that microorganisms in nature normally live under energy-limited conditions. LÄS MER
Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance. In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER
24. Design and synthesis of KDO-derivatives as inhibitors of lipopolysaccharide biosynthesis in Gram-negative bacteria : a new class of antibacterial agents
Sammanfattning : .... LÄS MER
25. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
Sammanfattning : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. LÄS MER