Sökning: "gram negative bacteria"

Visar resultat 21 - 25 av 209 avhandlingar innehållade orden gram negative bacteria.

  1. 21. Chromosomal β-lactamases in enterobacteria and in vivo evolution of β-lactam resistance

    Författare :Sven Bergström; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram negative bacteria; ß-lactamase genes; divergence of neighbouring cperons; ß-lactamase hyperproduction; evolution of control sequences;

    Sammanfattning : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. LÄS MER

  2. 22. Interactions between metals and bacteria : Importance for metal speciation

    Författare :Lena Brynhildsen; Linköpings universitet; []

    Sammanfattning : The objective of this thesis is to contribute to the understanding of the interactions between metals and microorganisms with respect to * Toxicity of metals (Cd, Cu, Hg, Zn) * Mineralization of metal-organic complexes (citric acid, histidine) * Metal adsorption (Cs, Sr, Eu, Hg, Zn, As) Most of the studies were made on the gram-negative bacterium Klebsiella oxytoca, but the work also involved a Serratia as as well as mixed cultures of microorganisms from soil systems. Most previous studies, reported in the literature, on the toxic effects of metals on microorganisms have been performed at high nutrient levels, despite the fact that microorganisms in nature normally live under energy-limited conditions. LÄS MER

  3. 23. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Författare :Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER

  4. 24. Design and synthesis of KDO-derivatives as inhibitors of lipopolysaccharide biosynthesis in Gram-negative bacteria : a new class of antibacterial agents

    Författare :Anita M. Jansson; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 25. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action

    Författare :Manuela Terrinoni; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ; vaccine development; plasmid maintenance; Gram-negative bacteria; essential genes; complementation; Cholera Toxin; adjuvanticity; NF-kB; mmCT; Gram-negative bacteria;

    Sammanfattning : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. LÄS MER