Sökning: "gp41"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet gp41.

  1. 1. Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells

    Författare :Fayezeh Yari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Phage display; vector; monoclonal antibody; antigen; eukaryotic; prokaryotic; transfection; selection; transient expression; stable cell line; neutralizing antibody; expression; HIVA-1; gp41; gp120;

    Sammanfattning : The main purpose of this study was to investigate and optimize techniques for eukaryotic expression of antibody molecules (IgG, Fab and scFV-ê formats), derived from an immune phage displayed Fab library and reactive against HIV-1 glycoproteins gp120 and gp41. Light and heavy-chain (Fd) DNA from a number of Fab clones were transferred from a prokaryotic phagemid vectors to mammalian expression vectors. LÄS MER

  3. 2. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

    Författare :Britt Losman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

  4. 3. Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity

    Författare :Alenka Jejcic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1;

    Sammanfattning : HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. LÄS MER

  5. 4. Co-evolution of the HIV-1 R5 phenotype and the viral envelope glycoproteins

    Författare :Johanna Repits; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; envelope; R5; HIV-1; evolution;

    Sammanfattning : To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. LÄS MER

  7. 5. Immune recognition and early virus-cell interactions. Glycobiological aspects on HIV-1 gp120

    Författare :Gregers J. Gram; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human immunodeficiency virus type 1 HIV-1 ; glycoprotein; gp120; glycosylation.;

    Sammanfattning : Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in humans. The viral envelope glycoproteins gp120 and gp41 mediate the early virus-cell interaction of HIV with the target cells. LÄS MER