Sökning: "glycosylation"

Visar resultat 6 - 10 av 193 avhandlingar innehållade ordet glycosylation.

1. 6. Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns

   Författare :Helén Brogren; Göteborgs universitet; []
   Nyckelord :PAI-1; platelets; plasma; fibrinolysis; synthesis; polymorphism; glycosylation; activity; platelet mRNA;

   Sammanfattning : Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present in high concentrations in platelets and also in low concentrations in plasma, but the source of plasma PAI-1 is not known. LÄS MER

3. 7. Shedding light on glycosylation : Analysis of complex carbohydrates using an affinity biosensor

   Författare :Mathias Liljeblad; Bengt Danielsson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The main objective during the work described in this thesis has been to develop assays for stodies of complex carbohydrates in a clinical context. Complex carbohydrates, such as free or protein linked oligosaccharides, have been shown to have important biological functions. LÄS MER

4. 8. Bacterial antibody hydrolyzing enzymes – as bacterial virulence factors and biotechnological tools

   Författare :Eleni Bratanis; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunoglobulins; Immunomodulation; Antibody mediated immunity; Glycosylation; Bacterial virulence; Bacterial enzymes; Biotechnology; streptococcus pyogenes; Bdellovibrio bacteriovorus;

   Sammanfattning : Antibodies are an essential part of the human immune system, and antibody mediated immunity has been an area of interest for many researchers for almost a century. An accumulation of knowledge regarding antibody structure, glycosylation and receptor interactions has contributed to the current understanding of antibody mediated immunity. LÄS MER

5. 9. Glycan dependent Helicobacter spp. and Streptococcus oralis binding to mucins in the gastric and oral mucosal niches

   Författare :Gurdeep Chahal; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; Streptococcus; diversity; glycosylation;

   Sammanfattning : Helicobacter pylori infects the stomach of half of the world’s population, while Helicobacter suis colonizes pigs and is the most common non-H. pylori Helicobacter species that also infects human stomach. Infection with Helicobacter spp. is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. LÄS MER

7. 10. Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain

   Författare :Carina Sihlbom; Göteborgs universitet; []
   Nyckelord :glycoproteomics; quantitative proteomics; glycoprotein; protein quantification; glycosylation; Fourier transform ion cyclotron mass spectrometry; cerebrospinal fluid; Alzheimer s disease; neurodegeneration; neuroregeneration; hippocampus; astrocytes; brain injury; 14-3-3 protein; isoform;

   Sammanfattning : Biological processes involve changes at the protein level. Proteomics aims to determine protein changes from a normal state, to measure for instance recovery or disease progression. Mass spectrometry is the most important tool for identification of proteins and determination of post-translational modifications such as glycosylation. LÄS MER