Sökning: "glycosylation"

Visar resultat 21 - 25 av 193 avhandlingar innehållade ordet glycosylation.

1. 21. Effects of galectins and antibodies in HIV infection; Novel Assays

   Författare :Enas Sheik-Khalil; Institutionen för laboratoriemedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; galectin-1; galectin-8; neutralizing antibodies; cell-cell fusion; Microscale anisotropy assay; virus binding assay; glycosylation; gp120; Automated plaque reduction assay; CellProfiler; NeutNet;

   Sammanfattning : The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. LÄS MER

3. 22. Studies towards ß-turn mimetics, synthesis of kedarosamine from threonine, and synthesis of glycopeptides from mucins and gp120

   Författare :Tatjana Vuljanic; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tn antigen; glycopeptides; glycosylation; diastereselective reduction; kedarosamine; kedarcidin chromophore; amino acids; peptide T; ß-turn mimetic; Organisk kemi; gp120; Organic chemistry;

   Sammanfattning : The secondary structure of proteins is crucial for proper function of the protein in biological systems. Peptide T, an octapeptide from the envelope glycoprotein gp120 of the HIV virus, has previously been shown to be responsible for binding to the CD4 receptor on T helper/inducer lymphocytes. LÄS MER

4. 23. Glycoconjugates : Solid-phase synthesis and biological applications

   Författare :Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

   Sammanfattning : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. LÄS MER

5. 24. Glycosylation in cancer and infection : the role of sialic acid

   Författare :Yuecheng Zhang; Anette Wingren; Maria Stollenwerk; Lars Ohlsson; Martin Dufva; Malmö universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer; sialic acids; receptor; molecularly imprinted polymers; SARS-CoV-2; fluorescence; Health and society; Hälsa och samhälle;

   Sammanfattning : Sialic acids (SA), a group of nine-carbon backbone monosaccharides are abundantly expressed in vertebrates. They are usually linked to the terminal of glycan chains and play crucial roles in many biological processes, including cell adhesion, cell-cell interactions, immune modulation, cancer cell migration and invasion, as well as viral infections. LÄS MER

7. 25. Streptococcus pyogenes secreted enzymes interacting with the human host

   Författare :Mattias Collin; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA fingerprinting; Streptococcus pyogenes; Clinical biology; immunoglobulins; Klinisk biologi; autoimmunity; endoglycosidase; cysteine proteinase; glycosylation;

   Sammanfattning : Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. LÄS MER