Sökning: "glycosylation profiling"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden glycosylation profiling.

1. 1. Development and application of alternative methods for profiling proteins N-glycosylation

   Författare :Alessandro Quaranta; Leopold Ilag; Niclas Karlsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-glycosylation; Glycomics; Glycosylation Biomarkers; Intact Glycoproteins; Glycoform Quantification; Mass Spectrometry; Ion Mobility Spectrometry; MALDI-MS; Paper Spray Ionization; Microfluidics; Magnetic Beads; Immunoaffinity Purification; Nanobodies; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. LÄS MER

3. 2. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

   Författare :Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. LÄS MER

4. 3. Advances and Applications of Antibody Arrays - Proteomic Profiling of Pancreatic Disease

   Författare :Anna Sandström Gerdtsson; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarray; pancreatic cancer; pancreatitis; biomarker; immunosignature;

   Sammanfattning : Recombinant antibody microarrays have advanced into indispensable tools for large-scale, high-throughput multiplexed serum proteomics. This thesis, based upon five original papers, deals with the development of an in-house designed antibody microarray platform, and its applications for serum profiling of pancreatic disease. LÄS MER

5. 4. Clinical studies on α1-acid glycoprotein glycosylation - with focus on fucose

   Författare :Ingvar Rydén; Joyce Carlson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : α1-Acid glycoprotein (AGP, orosomucoid) is a heavily glycosylated protein found in blood plasma in all humans. AGP is one of the major acute phase proteins, and its concentration is frequently measured in clinical laboratories as a marker for inflammatory disease. LÄS MER

7. 5. The role and synthesis of β1,3-galactans in plant cell wall formation

   Författare :Petrus Nibbering; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : The plant cell wall associated hydroxyproline rich glycoproteins (HRGPs) play an important role in cell wall formation, but the mechanisms are not well understood. The HRGP family consists of the heavily glycosylated arabinogalactan proteins (AGPs) and the moderately glycosylated extensins (EXTs) and proline rich proteins (PRPs). LÄS MER