Sökning: "glycosaminoglycan"

Visar resultat 16 - 20 av 85 avhandlingar innehållade ordet glycosaminoglycan.

  1. 16. Involvement of Heparan Sulphate Biosynthesis and Turnover in Cell Proliferation. A Novel Role for Nitric Oxide in Recycling of Heparan Sulphate Proteoglycans

    Författare :Katrin Mani; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nitrite.; nitric oxide; growth-inhibition; xyloside; glypican; heparan sulphate; Proteoglycan; glycosaminoglycan; Clinical biology; Klinisk biologi;

    Sammanfattning : The present investigation focuses on the role of HS metabolism in cell proliferation. The effect of the HS priming ß-D-xyloside, 2-(6-hydroxynaphthyl)-O-ß-D-xylopyranoside (Xyl-2-Nap-6-OH) on the proliferation of normal and transformed cells was studied. LÄS MER

  3. 17. Human studies evaluating dGEMRIC as a prognostic tool for knee osteoarthritis

    Författare :Henrik Owman; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Delayed gadolinium-enhanced MRI of cartilage dGEMRIC ; knee; cartilage; glycosaminoglycan; anterior cruciate ligament injury; meniscal injury; osteoarthritis; joint space narrowing; osteophyte;

    Sammanfattning : Osteoarthritis (OA) is the most common joint disorder worldwide, causing joint pain and stiffness. The current gold standard for diagnosing knee OA is radiography. However, the disease has often progressed well beyond the point of no return once radiographic cartilage changes become visible. LÄS MER

  4. 18. Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

    Författare :Andrea Persson; Glykobiologigruppen; []
    Nyckelord :Glycosaminoglycan; Xyloside; Chondroitin sulfate; Dermatan sulfate; Heparan sulfate; Proteoglycan; Cancer;

    Sammanfattning : Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. LÄS MER

  5. 19. In Vitro Studies of the Substrate Specificities of Heparan Sulfate 2-O- and 6-O-sulfotransferases

    Författare :Emanuel Smeds; Marion Kusche-Gullberg; Ulf Lindahl; Catherine L. R. Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; heparin; sulfotransferase; 2-O-sulfotransferase; 6-O-sulfotransferase; polysaccharide biosynthesis; glycosaminoglycan; O-sulfotransferase; proteoglycan; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Heparan sulfate (HS), a linear negatively charged polysaccharide located at the cell surface and in the extracellular matrix, interacts with, and thereby regulates the functions of numerous proteins. HS-protein interactions depend on the fine structure of HS, especially its sulfation pattern. LÄS MER

  7. 20. Formation of Iduronic Acid during Chondroitin/Dermatan Sulfate Biosynthesis

    Författare :Emil Tykesson; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLYCOSAMINOGLYCAN; CHONDROITIN; DERMATAN; EPIMERASE; SULFOTRANSFERASE; GLYCOSAMINOGLYCAN; CHONDROITIN SULFATE; DERMATAN SULFATE; EPIMERASE; SULFOTRANSFERASE;

    Sammanfattning : All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. LÄS MER