Sökning: "glycoprotein gene"

Visar resultat 21 - 25 av 82 avhandlingar innehållade orden glycoprotein gene.

1. 21. Structural and evolutionary studies of a lipocalin: the alpha1-microglobulin protein and its gene

   Författare :Annika Lindqvist; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryology human ; ontogeny; teratology; AMBP; Development biology; protein HC; bikunin; Utvecklingsbiologi; teratologi; embryologi människa ; Genetics; cytogenetics; Genetik; cytogenetik;

   Sammanfattning : a1-microglobulin is a small glycoprotein present in plasma and in tissues surrounding the gastrointestinal and respiratory tracts. a1-microglobulin is a member of the lipocalin protein family and exhibits several of the typical traits of a lipocalin; it binds an unknown ligand which causes the brown color of the protein, it forms complexes with various different proteins and there have been indications of the presence of a receptor for a1-microglobulin on T-lymphocytes. LÄS MER

3. 22. Molecular mechanisms in obesity-associated metabolic disease

   Författare :Louise Olofsson; Göteborgs universitet; []
   Nyckelord :obesity; metabolic syndrome; cholesterol; resting metabolic rate; insulin resistance; serum amyloid A; S100 calcium binding protein A1; Zn-alpha2-glycoprotein; CCAAT enhancer binding protein alpha;

   Sammanfattning : Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. LÄS MER

4. 23. Novel endogenous mechanisms of complement regulation - A delicate balance

   Författare :Andreas Holmér; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

   Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER

5. 24. Genetic regulation of autoimmune neuroinflammation

   Författare :Kristina Becanovic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MS; EAE; QTL; gene regulation; linkage analysis;

   Sammanfattning : Multiple sclerosis (MS) is a complex disease characterized by inflammation and demyelination in the central nervous system (CNS), causing neurological deficits. Although there is an increased familial aggregation rate and evidence for a genetic influence on disease susceptibility, environmental factors are also of importance. LÄS MER

7. 25. The complex genetics of experimental autoimmune neuroinflammation

   Författare :Maja Jagodic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :EAE; MS; QTL; AIL; linkage analysis; gene regulation;

   Sammanfattning : Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system (CNS). MS is the second most common cause of neurological disability among young adults in the western world. LÄS MER