Sökning: "glycoprotein c"

Visar resultat 1 - 5 av 60 avhandlingar innehållade orden glycoprotein c.

  1. 1. P-glycoprotein and chiral antidepressant drugs : Pharmacokinetic, pharmacogenetic and toxicological aspects

    Författare :Louise Karlsson; Fredrik C. Kugelberg; Finn Bengtsson; Johan Ahlner; Aleksander A. Mathé; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. LÄS MER

  3. 2. Developmental Aspects of Drug Transport Across the Blood-Brain Barrier

    Författare :Jörgen Bengtsson; Margareta Hammarlund-Udenaes; Ann-Cathrin Engwall; Sven Björkman; Elizabeth C.M. de Lange; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; development; active transport; tight junction proteins; microdialysis; recovery; morphine; nitrofurantoin; Bcrp; microarray; real-time PCR; in vitro; in vivo; LC-MS MS; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The developmental aspect of drug transport across the blood-brain barrier (BBB) was investigated. Microdialysis was used to study unbound morphine BBB transport at different ages in sheep. An in vitro study was performed to find differentially expressed genes in brain capillary-rich fractions of the brain in rats of different ages. LÄS MER

  4. 3. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Författare :Kristina Mårdberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Sammanfattning : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. LÄS MER

  5. 4. Bacteria-agglutinating glycoproteins in human saliva : an in vitro study with special reference to Streptococcus mutans

    Författare :Jan Rundegren; Umeå universitet; []
    Nyckelord :agglutinin; glycoprotein; saliva; streptococcus mutans;

    Sammanfattning : The activity and specificity of salivary glycoproteins (agglutinins) aggregating various human indigenous microorganisms were studied in vitro. The agglutinin reacting with a serotype c strain of Streptococcus mutans was isolated and chemically characterized.The results can be summarized as follows:1. LÄS MER

  7. 5. Coagulation, Inflammation and Myocardial Dysfunction in Unstable Coronary Artery Disease and the Influence of Glycoprotein IIb/IIIa Inhibition and Low Molecular Weight Heparin

    Författare :Stefan James; Lars Wallentin; Agneta Siegbahn; Robbert de Winter; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Acute coronary syndrome; Angina; Mortality; Myocardial infarction; Glycoprotein IIb IIIa inhibition; Troponin; C-reactive protein; Coagulation; Natriuretic peptide; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; kardiologi; Cardiology;

    Sammanfattning : Hjärt-kärl sjukdom är den vanligaste dödsorsaken i västvärlden. Samtidigt som antalet patienter med hjärtinfarkt har minskat, har antalet patienter med instabil kranskärlsjukdom d.v.s. LÄS MER