Sökning: "glycoprotein B"

Visar resultat 1 - 5 av 51 avhandlingar innehållade orden glycoprotein B.

  1. 1. Obesity and Increased Susceptibility : Role of FTO and MGAT1 Genetic Variants

    Författare :Josefin A Jacobsson; Robert Fredriksson; Helgi B Schiöth; Sadaf Farooqi; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; BMI; SNP; haplotype; association study; FTO; MGAT1; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Sammanfattning : Obesity is a complex and a highly individualized disease and the molecular mechanisms behind this disorder need to be better elucidated. Identification of genes and genetic variants that are involved provide opportunities to establish a genetic understanding of the disease. LÄS MER

  2. 2. Defining the role of CD47 and SIRPα in murine B cell homeostasis

    Författare :Shrikant S Kolan; Per-Arne Oldenborg; Mikael Karlsson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; CD47; SIRPα; Follicular B cell; Marginal zone macrophages; immunologi; Immunology;

    Sammanfattning : B cell development is a highly organized process, which commences in the fetal liver during embryogenesis and in the bone marrow (BM) after birth. Surface IgM+ immature B cells emigrate from the BM via the blood stream to the spleen and finally differentiate into conventional mature follicular B (FoB) cells and marginal zone (MZ) B cells. LÄS MER

  3. 3. Antibody Evolution and Repertoire Development

    Författare :Johan Lantto; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; virus neutralization; trinucleotide repeat; insertion; immunoglobulin variable genes; human cytomegalovirus; glycoprotein B; deletion; antibody; antibody repertoire;

    Sammanfattning : Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. LÄS MER

  4. 4. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

    Författare :Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

    Sammanfattning : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. LÄS MER

  5. 5. Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?

    Författare :Michel Silvestri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; CMV; HCMV; gB; autoimmunity; cross-reactivity; epitope analysis electrochemiluminescence; heparin; heparan sulphate; neutralising antibodies;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a significant factor in morbidity, why there is clearly a need for effective therapy and prophylaxis against HCMV infection. LÄS MER