Sökning: "glycopeptide"

Visar resultat 6 - 10 av 20 avhandlingar innehållade ordet glycopeptide.

1. 6. Staphylococcal prosthetic joint infections : similar, but still different

   Författare :Staffan Tevell; Bo Söderquist; Åsa Nilsdotter-Augustinsson; Annelies Zinkernagel; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prosthetic joint infections; staphylococcal infections; nasal carriage; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus capitis; NRCS-A; antibiotic resistance; heterogeneous glycopeptide resistance; whole-genome sequencing; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : Staphylococci constitute a major part of our commensal flora but are also the most common bacteria causing prosthetic joint infections (PJIs), a dreaded complication of arthroplasty surgery. However, not all staphylococci are the same. LÄS MER

3. 7. The effect of Gal alpha(1,3)gal glycopeptide-conjugates and human serum on HIV-1 infection and replication

   Författare :Maria Fernanda Perdomo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The first step in the entry of HIV-1 is the binding of the viral envelope glycoprotein (gp120) to the CD4 molecule expressed mainly on T helper cells. Upon binding, gp120 undergoes a series of conformational changes that expose inner epitopes, which in turn facilitate binding to the viral co-receptors (CCR5 or CXCR4). LÄS MER

4. 8. Asymmetric Synthesis of C-Glycosylated Amino Acids : Incorporation in Collagen Glycopeptides and Evaluation in a Model for Rheumatoid Arthritis

   Författare :Tomas Gustafsson; Jan Kihlberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Total synthesis; stereoselective synthesis; chiral glycine templates; Evan’s alkylation; asymmetric hydrogenation; alpha-amino acid synthesis; C-glycoside; rheumatoid arthritis; MHC; T cell; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis describes stereoselective syntheses of four amino acids, three of which are C-glycosidic analogues of glycosylated amino acids. The overall goal of the project was to probe the interactions between MHC molecules, glycopeptide antigens and T cell receptors, that are essential for development of collagen induced arthritis. LÄS MER

5. 9. Development and Evaluation of Tools to Explore Posttranslational HexNAc-Tyrosine and Mucin-Type O-Glycosylation

   Författare :Sandra Behren; Ulrika Westerlind; Mikael Elofsson; Carmen Galan; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycopeptides; mucins; mucin type-O-glycosylation; microarrays; tyrosine-O-HexNAcylation; lectins; MUC1 cancer vaccines; TcdA; LecB; galectins; LacdiNAc; antibodies; biologisk kemi; biological chemistry; Biorganic Chemistry; bioorganisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Glycosylation is the most abundant form of post-translational modification (PTM). Recently, O-glycosylation attracted much attention in the glycoproteomic field due to its association with various diseases, such as pathogenic infections and cancer. LÄS MER

7. 10. Binding and immunogenicity of MHC class-I specific peptides and glycopeptides

   Författare :Ussama M Abdel-Motal; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Short synthetic MHC class I (MHC-I) Db and Kb binding peptides were found to be strongly immunogenic and capable of inducing virus-specific cytotoxic T lymphocyte (CTL) responses. Restimulation of primed splenocytes with a low peptide concentration generated optimal CTL responses. LÄS MER