Sökning: "glycopeptide"

Visar resultat 11 - 15 av 20 avhandlingar innehållade ordet glycopeptide.

1. 11. Protein mass spectrometry in the drug discovery process

   Författare :Agneta Tjernberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mass spectrometry; ESI-MS; MALDI-TOF MS; drug discovery; protein characterization; dissociation constants;

   Sammanfattning : Most targets for drug discovery are proteins. Drug discovery includes target identification and validation, structural biology, lead generation, lead optimisation, pre-clinical development and clinical trials. The overall aim of this thesis is to apply protein mass spectrometry (MS) in the early drug discovery process. LÄS MER

3. 12. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase

   Författare :Cecilia Lindgren; Anna Linusson; Antti Poso; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; class II MHC protein; drug design; molecular dynamics simulation; multicomponent system; nerve agent; oxime; quantitative structure-activity relationship; reactivator; rheumatoid arthritis; statistical molecular design; T-cell receptor;

   Sammanfattning : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. LÄS MER

4. 13. Moleculary imprinted micro- and nanoparticles for cancer associated glycan motifs

   Författare :Liliia Mavliutova; Börje Sellergren; Michael Whitcombe; Malmö universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Moleculary imprinted polymer; sialic acid; glycan recognition; synthetic receptor;

   Sammanfattning : Sialic acids are an important family of monosaccharides that are typically found as terminal moieties of glycans. Aberrant sialylation has been proven to correlate with various diseases including cancer. Glycosylation analysis is complex due to high diversityof the glycan isomers and their low abundance. LÄS MER

5. 14. Coagulase-negative staphylococci in hematological malignancy

   Författare :Erik Ahlstrand; Bo Söderquist; Ulf Tidefelt; Karlis Pauksens; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coagulase-negative staphylococci; hematological malignancy; Staphylococcus epidermidis; healthcare-associated infection; antibiotic susceptibility; molecular epidemiology; bloddstream infection; bacteremia; Medicine; Medicin;

   Sammanfattning : Bacterial infections are common in hematological malignancy. Coagulase-negative staphylococci (CoNS) are among the most prevalent causes of bacteremia in patients with hematological malignancies. LÄS MER

7. 15. T cells in Autoimmunity: studies on murine type II collagen-induced arthritis

   Författare :Alexandre Corthay; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; Autoimmunity T lymphocytes collagen-induced arthritis Glycosylation TCR; transplantation; serology; Immunology; serologi; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

   Sammanfattning : Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. LÄS MER