Sökning: "glycolytic pathway"
Visar resultat 1 - 5 av 29 avhandlingar innehållade orden glycolytic pathway.
1. Mechanism of Metabolite transfer between Enzymes in Glycolysis and Connected Pathways
Sammanfattning : The metabolite produced by one enzyme in a metabolic pathway can be transferred to the next enzyme in the pathway by free diffusion via solution or by channelling in an enzyme-enzyme complex without prior release of the metabolite to solution. While metabolite channelling is known to occur in systems where stable multienzyme complexes form, conflicting views have been expressed as to its existence in pathways involving "soluble" enzymes. LÄS MER
2. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes
Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER
3. T-Cell Protein Tyrosine Phosphatase, a Regulator of the PDGF Signaling Pathway
Sammanfattning : Platelet-derived growth factor (PDGF) is a potent stimulator of cell growth, survival and motility. PDGF exerts its function by binding to specific tyrosine kinase receptors, initiating receptor auotphosphorylation and initiation of specific signaling pathways that regulates the cellular response. LÄS MER
4. The Role of Hexose Transport on Glycolytic Flux and Glucose Induced Responses in Saccharomyces cerevisiae
Sammanfattning : In the yeast Saccharomyces cerevisiae, glucose is primarily fermented rather than respired. Only in cultivation modes such as chemostats or fed-batches, where the external glucose is kept low, a fully respiratory catabolism is observed. LÄS MER
5. Functional studies of the TDH and GPD gene-products in the glycolytic flux and glycerol metabolism of Saccharomyces cerevisiae
Sammanfattning : This thesis focuses on the physiology and control of the glycolysis and glycerol metabolism in the yeast Sacchromyces cerevisiae. The study is based on the relation ship between the first two reactions around the branch-point of the upper and lower part of glycolysis and the glycerol pathway. LÄS MER