Sökning: "glycobiology"

Visar resultat 11 - 15 av 15 avhandlingar innehållade ordet glycobiology.

  1. 11. Glycoconjugates : Solid-phase synthesis and biological applications

    Författare :Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

    Sammanfattning : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. LÄS MER

  3. 12. Biochemical studies of carbohydrate blood group antigens - Carbohydrate phenotype in relation to cellular glycosyltranferases

    Författare :Mette Diswall; Göteborgs universitet; []
    Nyckelord :glycosphingolipid; glycosyltransferase; genetic modification; carbohydrate; mass spectrometry; proton NMR spectroscopy; xenotransplantation; GalT-KO pig;

    Sammanfattning : The possibility to alter the cell surface carbohydrate expression by insertion or deletion of glycosyltransferase genes is a powerful technique to study the biological function of selected carbohydrate antigens. However, shifting the equilibrium between competing glycosyltransferases might lead to unexpected phenotypic effects, such as accumulation of other carbohydrate antigens and exposure of antigen structures that normally are cryptic or present in minute amounts on the cell surface. LÄS MER

  4. 13. Identification and functional analysis of anti-citrullinated protein antibodies in rheumatoid arthritis

    Författare :Yibo He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a complex autoimmune disease and typically manifested by joint inflammation and bone erosion with approximately 0.5% of the global population affected. To date, it is believed that genetic predisposition (e.g. LÄS MER

  5. 14. Design and Synthesis of Glycomimetics as Selective Galectin Inhibitors

    Författare :Mukul Mahanti; Centrum för analys och syntes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitors; Glycomimentics; Epimeric switch; MD simulation;

    Sammanfattning : In last couple of decades the field of glycobiology has developed rapidly due to the increased understanding of glycans’ abilities to encode biological information, which may have impact on biological event and disease, such as for example tumour growth and inflammation. This development has been accompanied by an increasing focus on drug discovery revolving around a category of carbohydrate-based drugs termed glycomimetics. LÄS MER

  7. 15. Studies of the ABO and FORS Histo-Blood Group Systems: Focus on Flow Cytometric and Genetic Analysis

    Författare :Annika Hult; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood Group; ABO; Weak expression; FORS; Flow cytometry;

    Sammanfattning : ABO is the clinically most important blood group system and its antigens are carbohydrate moieties present on the surface of the red blood cell (RBC) but also on other tissues throughout the body. The ABO gene encodes an enzyme, a glycosyltransferase (GT),that adds a terminal monosaccharide to the precursor structure, H antigen, to define the A or B antigens. LÄS MER