Sökning: "glucocorticoids"

Visar resultat 26 - 30 av 160 avhandlingar innehållade ordet glucocorticoids.

1. 26. Development and Resolution of Allergic Airway Inflammation in vivo: effects of therapeutic intervention

   Författare :Lena Uller; Lungbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Andningsorganen; Respiratory system; Medicin människa och djur ; Medicine human and vertebrates ; Animal models; Glucocorticoids; Eosinophils; Apoptosis; Asthma; Allergy;

   Sammanfattning : Eosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. LÄS MER

3. 27. Pharmacological and genetic manipulation of adipose cell differentiation and metabolism

   Författare :Milica Vranic; Maria J. Pereira; Jan Eriksson; Niklas Mejhert; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; adipocyte; type 2 diabetes; CRISP Cas9; FKBP51; CDKN2C; second-generation antipsychotics; glucocorticoids; dopamine; dopamine receptor;

   Sammanfattning : Adipose tissue dysfunction has a pivotal role in the development of obesity and related metabolic complications, such as insulin resistance, cardiovascular disease, and diabetes. The overall aim was to study the consequences of adipose exposure to pharmacological agents, as well as dysregulations in the expression of genes, potentially involved in adipose tissue dysfunction and related metabolic impairments. LÄS MER

4. 28. The effects of glucocorticoids on brown fat : physiological and molecular studies

   Författare :Ineke Luijten; Jan Nedergaard; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Brown adipose tissue (BAT) is the main site for non-shivering thermogenesis in most mammals. The BAT-specific uncoupling protein-1 (UCP1) uncouples substrate oxidation from ATP production and hereby decreases metabolic efficiency. LÄS MER

5. 29. Molecular mechanisms of glucocorticoids : anti-inflammatory implications

   Författare :Krishan Johansson-Haque; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glucocorticoids (GCs) play important roles in many biological processes including inflammatory responses. The study of this process has involved investigations of cross-talk abilities by GC receptor (GR) with cellular signaling pathways that have been associated with inflammatory disorders or implicated as contributory for the adverse effects observed with GC therapy. LÄS MER

7. 30. Prevention of growth failure caused by glucocorticoids and inflammation

   Författare :Bettina Celvin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Longitudinal bone growth is a complex process that takes place in the growth plate, and normal growth is dependent on a precise balance of several endocrine and paracrine factors. Growth impairment is common in children with inflammatory diseases and is associated with elevated levels of pro-inflammatory cytokines and long-term glucocorticoid treatment. LÄS MER