Sökning: "glucocorticoid receptor"

Visar resultat 21 - 25 av 95 avhandlingar innehållade orden glucocorticoid receptor.

  1. 21. Prevention of growth failure caused by glucocorticoid treatment

    Författare :Yunhan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Children with chronic inflammation often suffer from growth failure and many of these children are treated with high doses of glucocorticoids (GCs). However, the underlying mechanisms of growth failure under conditions of chronic inflammation and the relative contributions of inflammation per se and commonly used GC treatment are still unknown. LÄS MER

  3. 22. Glucocorticoid administration : studies on weight regulation and metabolic implications

    Författare :Joanna Uddén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glucocorticoids; leptin; obesity; adipose tissue; PAI-1; UCP-2; cortisol; the metabolic syndrome; 11 beta-HSD; eating behaviour; weight gain.;

    Sammanfattning : Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have been suggested to play a role in development of visceral fat accumulation. LÄS MER

  4. 23. Novel mechanisms of glucocorticoid-induced insulin resistance in human adipose tissue

    Författare :Cherno Omar Sidibeh; Jan Eriksson; Maria João Pereira; Anna Krook; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid receptor type 1 fkbp51 dexamethasone type 2 diabetes adipocytes; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The global prevalence of obesity and type 2 diabetes (T2D) is increasing. From a public health perspective, it is therefore of interest to identify common underlying mechanisms of these comorbidities. Glucocorticoids are steroid hormones that are important in stress regulation in mammals. LÄS MER

  5. 24. Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release

    Författare :Behrous Davani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glucocorticoids; glucocorticoid receptor; Pancreatic beta-cell; Type 2 diabetes; insulin release;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic beta-cells. Glucocorticoids (GCs) exert profound effects on glucose homeostasis. LÄS MER

  7. 25. Pharmacological and genetic manipulation of adipose cell differentiation and metabolism

    Författare :Milica Vranic; Maria J. Pereira; Jan Eriksson; Niklas Mejhert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; adipocyte; type 2 diabetes; CRISP Cas9; FKBP51; CDKN2C; second-generation antipsychotics; glucocorticoids; dopamine; dopamine receptor;

    Sammanfattning : Adipose tissue dysfunction has a pivotal role in the development of obesity and related metabolic complications, such as insulin resistance, cardiovascular disease, and diabetes. The overall aim was to study the consequences of adipose exposure to pharmacological agents, as well as dysregulations in the expression of genes, potentially involved in adipose tissue dysfunction and related metabolic impairments. LÄS MER