Sökning: "glioma stem cells"

Visar resultat 21 - 25 av 34 avhandlingar innehållade orden glioma stem cells.

  1. 21. Modeling glioblastoma heterogeneity to decipher its biology

    Författare :Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. LÄS MER

  3. 22. Molecular regulation and analysis of neural stem and cancer cell characteristics

    Författare :Amilcar Reis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Every single cell within an organism is constantly facing the demanding task of preserving the integrity of its genomic material to secure proper function and clearance from disease. To accomplish this cells rely on DNA repair mechanisms that are well- conserved throughout evolution and highly specialized in removing particular types of DNA damage. LÄS MER

  4. 23. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase

    Författare :Zahidul Khan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malignant glioma; suicide gene therapy; bystander effect; gap junction; neural stem cell; 4-phenylbutyrate; epigenetics; cell differentiation;

    Sammanfattning : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. LÄS MER

  5. 24. Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors

    Författare :Kaveh M Goudarzi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gliomas are known to be the most prevalent primary tumors of the central nervous system, of which glioblastoma is the most aggressive type with a median survival less than 2 years and no available cure. Studies in this thesis investigated the significance of two potentially important proteins in glioma biology, the transcription factor PROX1 and the histone chaperone NPM1, and the interplay of the therapeutic targets p53 and mTOR. LÄS MER

  7. 25. Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment

    Författare :Vasiliki Pantazopoulou; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; glioblastoma; tumor microenvironment; reactive astrocytes; hypoxia; CD44; p75NTR;

    Sammanfattning : Glioblastoma is the most aggressive primary brain tumor in adults. Despite treatment, tumors invariably recur, and the recurring tumor is resistant to therapies. New approaches are needed for the successful treatment of glioblastoma patients.Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. LÄS MER